19216-56-9
19216-56-9
Chemical Structure
Prazosin
- CAS No.: 19216-56-9
- Formula:C19H21N5O4
- Molecular Weight:383.40
IUPAC Name: (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone
InChIKey: IENZQIKPVFGBNW-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4=CC=CO4
Biological Activity: Prazosin is an α-adrenergic receptor antagonist. Prazosin can reduce inflammation, relieve anxiety, alleviate panic, prevent memory decline, and modulate the pain-relieving effects of opioids. Prazosin can be used in the study of hypertension and Alzheimer’s disease[1][2][3][4].
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Prazosin | 99.80% | Prazosin is an α-adrenergic receptor antagonist. Prazosin can reduce inflammation, relieve anxiety, alleviate panic, prevent memory decline, and modulate the pain-relieving effects of opioids. Prazosin can be used in the study of hypertension and Alzheimer’s disease. | ||||||||||||||||||||
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Prazosin (Standard) | ≥98% | Prazosin (Standard) is the analytical standard of Prazosin. This product is intended for research and analytical applications. 0 | ||||||||||||||||||||
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Prazosin-d8 | 98.0% | Prazosin-d8 is the deuterium labeled Prazosin. Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder. | ||||||||||||||||||||
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References
- [1]. Day HE, et al. Distribution of alpha 1a-, alpha 1b- and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord. J Chem Neuroanat. 1997 Jul;13(2):115-39. [Content Brief]
- [2]. Loukia Katsouri, et al. Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease. Neurobiol Aging. 2013 Apr;34(4):1105-15. [Content Brief]
- [3]. Elizabeth K Lucas, et al. Prazosin during fear conditioning facilitates subsequent extinction in male C57Bl/6N mice. Psychopharmacology (Berl). 2019 Jan;236(1):273-279. [Content Brief]
- [4]. Umit Kazim Ozdoğan, et al. Influence of prazosin and clonidine on morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol. 2003 Jan 24;460(2-3):127-34. [Content Brief]
