1. GPCR/G Protein
    Neuronal Signaling
    Autophagy
  2. Adrenergic Receptor
    Autophagy
  3. Prazosin hydrochloride

Prazosin hydrochloride 

Cat. No.: HY-B0193A Purity: 99.73%
Handling Instructions

Prazosin hydrochloride is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

For research use only. We do not sell to patients.

Prazosin hydrochloride Chemical Structure

Prazosin hydrochloride Chemical Structure

CAS No. : 19237-84-4

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg USD 86 In-stock
Estimated Time of Arrival: December 31
500 mg USD 190 In-stock
Estimated Time of Arrival: December 31
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Description

Prazosin hydrochloride is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder. Target: Adrenergic Receptor Prazosin hydrochloride, is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. It is an alpha-adrenergic blocker that is specific for the alpha-1 receptors. These receptors are found on vascular smooth muscle, where they are responsible for the vasoconstrictive action of norepinephrine. They are also found throughout the central nervous system. As of 2013, Prazosin (hydrochloride) is off-patent in the US, and the FDA has approved at least one generic manufacturer. In addition to its alpha-blocking activity, Prazosin (hydrochloride) is an antagonist of the MT3 receptor (which is not present in humans), with selectivity for this receptor over the MT1 and MT2 receptors. Prazosin hydrochloride is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity. However, when Prazosin (hydrochloride) is initially started, heart rate and contractility go up in order to maintain the pre-treatment blood pressures because the body has reached homeostasis at its abnormally high blood pressure. The blood pressure lowering effect becomes apparent when Prazosin (hydrochloride) is taken for longer periods of time. The heart rate and contractility go back down over time and blood pressure decreases.

Clinical Trial
Molecular Weight

419.86

Formula

C₁₉H₂₂ClN₅O₄

CAS No.

19237-84-4

SMILES

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4=CC=CO4.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (59.54 mM; Need ultrasonic)

H2O : 1 mg/mL (2.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3817 mL 11.9087 mL 23.8175 mL
5 mM 0.4763 mL 2.3817 mL 4.7635 mL
10 mM 0.2382 mL 1.1909 mL 2.3817 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.95 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

PrazosinAdrenergic ReceptorAutophagyBeta ReceptorInhibitorinhibitorinhibit

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Prazosin hydrochloride
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HY-B0193A
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