1. GPCR/G Protein
    Neuronal Signaling
    Autophagy
  2. Adrenergic Receptor
    Autophagy
  3. Prazosin hydrochloride

Prazosin hydrochloride 

Cat. No.: HY-B0193A Purity: 99.93%
Handling Instructions

Prazosin hydrochloride is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

For research use only. We do not sell to patients.

Prazosin hydrochloride Chemical Structure

Prazosin hydrochloride Chemical Structure

CAS No. : 19237-84-4

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10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg USD 86 In-stock
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500 mg USD 190 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Prazosin hydrochloride:

Top Publications Citing Use of Products

Publications Citing Use of MCE Prazosin hydrochloride

    Prazosin hydrochloride purchased from MCE. Usage Cited in: Biomed Pharmacother. 2020 Jan 16;124:109731.

    The expression of TNS1 in U937 and HL60 cells treated with different concentration of Prazosin is detected by Western blot analysis
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    Description

    Prazosin hydrochloride is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder. Target: Adrenergic Receptor Prazosin hydrochloride, is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. It is an alpha-adrenergic blocker that is specific for the alpha-1 receptors. These receptors are found on vascular smooth muscle, where they are responsible for the vasoconstrictive action of norepinephrine. They are also found throughout the central nervous system. As of 2013, Prazosin (hydrochloride) is off-patent in the US, and the FDA has approved at least one generic manufacturer. In addition to its alpha-blocking activity, Prazosin (hydrochloride) is an antagonist of the MT3 receptor (which is not present in humans), with selectivity for this receptor over the MT1 and MT2 receptors. Prazosin hydrochloride is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity. However, when Prazosin (hydrochloride) is initially started, heart rate and contractility go up in order to maintain the pre-treatment blood pressures because the body has reached homeostasis at its abnormally high blood pressure. The blood pressure lowering effect becomes apparent when Prazosin (hydrochloride) is taken for longer periods of time. The heart rate and contractility go back down over time and blood pressure decreases.

    Clinical Trial
    Molecular Weight

    419.86

    Formula

    C₁₉H₂₂ClN₅O₄

    CAS No.

    19237-84-4

    SMILES

    O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4=CC=CO4.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (59.54 mM; Need ultrasonic)

    H2O : 1 mg/mL (2.38 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3817 mL 11.9087 mL 23.8175 mL
    5 mM 0.4763 mL 2.3817 mL 4.7635 mL
    10 mM 0.2382 mL 1.1909 mL 2.3817 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.95 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.95 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.95 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    PrazosinAdrenergic ReceptorAutophagyBeta ReceptorInhibitorinhibitorinhibit

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    Product Name:
    Prazosin hydrochloride
    Cat. No.:
    HY-B0193A
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