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Inflachromene 

Cat. No.: HY-113772 Purity: >96.0%
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Inflachromene is a microglial inhibitor with anti-inflammatory effects. Inflachromene effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage in vivo. Inflachromene can be used for the research of neuroinflammatory disorders.

For research use only. We do not sell to patients.

Inflachromene Chemical Structure

Inflachromene Chemical Structure

CAS No. : 908568-01-4

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Inflachromene is a microglial inhibitor with anti-inflammatory effects. Inflachromene effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage in vivo. Inflachromene can be used for the research of neuroinflammatory disorders[1][2].

IC50 & Target

HMGB[2]

In Vitro

Inflachromene (0.01-100 μM; 24 h) efficiently blocks LPS-induced nitrite release in a dose-dependent manner without any toxicity in BV-2 microglial cells[2].
Inflachromene (1-10 μM) suppresses the increased levels of inflammation-related genes, such as Il6, Il1b, Nos2 and Tnf, after LPS stimulation[2].
Inflachromene (5 μM) reduces LPS-induced secretion of the proinflammatory cytokine TNF-α[2].
Inflachromene (5 μM; 30 min) substantially suppresses the nuclear translocation of NF-κB and the degradation of IκB[2].
Inflachromene (1-10 μM; 30 min) inhibits LPS-induced phosphorylation of ERK, JNK and p38 MAPK in microglia[2].
Inflachromene (10 μM; 30 min) completely prevents the death of cocultured neuroblastoma and primary neuronal cells by inhibiting microglia-mediated neurotoxicity[2].
Inflachromene (1-10 μM; 24 h) has no significant effect on the viability of neurons[2].

In Vivo

Inflachromene (2-10 mg/kg; i.p. once daily for 4 days) effectively blocks LPS-mediated microglial activation[2].
Inflachromene (10 mg/kg; i.p. once daily for 30 days) significantly reduces the progression of disease, as determined by EAE clinical score[2].
Inflachromene (1 mg/kg; i.v.) exhibits long half-life (14.1±6.43 h) and moderate Vss (2.02±1.02 L/kg)[1].
Inflachromene (1 mg/kg; p.o.) exhibits high oral bioavailability (94%) and Cmax (0.59±0.16 g/mL)[1].

Animal Model: Male C57BL/6 mice (11 weeks; 25-30 g) are treated with LPS[2]
Dosage: 2, 10 mg/kg
Administration: I.p. once daily for 4 days
Result: Blocked LPS-mediated microglial activation, even at a dose of 2 mg/kg.
Animal Model: Sprague-Dawley (SD) rats (7 weeks; 230-250 g)[1]
Dosage: 1 mg/kg (Pharmacokinetic Analysis)
Administration: I.v. and p.o. administration
Result: I.v.: t1/2=14.1±6.43 h; CL= 0.14±0.01 L/kg/h; Vss=2.02±1.02 L/kg.
P.o.: t1/2=7.96±1.16 h; F=94%; Cmax=0.59±0.16 g/mL.
Molecular Weight

377.39

Formula

C₂₁H₁₉N₃O₄

CAS No.

908568-01-4

SMILES

O=C1N(C2=CC=CC=C2)C(N3CC=C(C(C)(C)OC4=CC(O)=CC=C45)C5N31)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References

Purity: >96.0%

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Keywords:

InflachromeneOthersmicroglialanti-inflammatoryHMGBneuronalInhibitorinhibitorinhibit

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Inflachromene
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