1. NF-κB
    Immunology/Inflammation
  2. NF-κB
    NO Synthase
  3. Isoquercetin

Isoquercetin (Synonyms: Quercetin 3-glucoside)

Cat. No.: HY-N1445 Purity: 99.87%
Handling Instructions

Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies.

For research use only. We do not sell to patients.

Isoquercetin Chemical Structure

Isoquercetin Chemical Structure

CAS No. : 482-35-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
25 mg USD 160 In-stock
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Description

Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway[1]. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies[2].

In Vitro

Isoquercetin (Quercetin 3-glucoside; 5-20 μM; 24 hours) substantially reduces ethanol-induced cytotoxicity , protects hepatic cells against ethanol-stimulated liver injury[1]. Isoquercetin (10 μM; pre-treat 1 hour) dramatically downregulates the levels of ethanol-induced iNOS protein expression in HepG2 cells[1].

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 24 hours
Result: Caused significantly enhanced cell viability as positive controls.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 10 μM
Incubation Time: 1 hour
Result: Decreased ethanol‐ induced iNOS protein expression.
Clinical Trial
Molecular Weight

464.38

Formula

C₂₁H₂₀O₁₂

CAS No.

482-35-9

SMILES

O=C1C(O[[email protected]]2[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]@H](CO)O2)O)O)O)=C(C3=CC=C(O)C(O)=C3)OC4=CC(O)=CC(O)=C14

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 19.23 mg/mL (41.41 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1534 mL 10.7670 mL 21.5341 mL
5 mM 0.4307 mL 2.1534 mL 4.3068 mL
10 mM 0.2153 mL 1.0767 mL 2.1534 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.92 mg/mL (4.13 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.92 mg/mL (4.13 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.92 mg/mL (4.13 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

IsoquercetinQuercetin 3-glucosideNF-κBNO SynthaseNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSInhibitorinhibitorinhibit

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Isoquercetin
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HY-N1445
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