1. NF-κB
    Immunology/Inflammation
  2. NF-κB
    NO Synthase
  3. Quercetin 3-glucoside

Quercetin 3-glucoside 

Cat. No.: HY-N1445
Handling Instructions

Quercetin-3-glucoside is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Quercetin-3-glucoside alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Quercetin-3-glucoside regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Quercetin-3-glucoside has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies.

For research use only. We do not sell to patients.

Quercetin 3-glucoside Chemical Structure

Quercetin 3-glucoside Chemical Structure

CAS No. : 482-35-9

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Description

Quercetin-3-glucoside is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Quercetin-3-glucoside alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway[1]. Quercetin-3-glucoside regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Quercetin-3-glucoside has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies[2].

In Vitro

Quercetin-3-glucoside (5-20 μM; 24 hours) substantially reduces ethanol-induced cytotoxicity , protects hepatic cells against ethanol‐stimulated liver injury[1]. Quercetin-3-glucoside (10 μM; pre-treat 1 hour) dramatically downregulates the levels of ethanol-induced iNOS protein expression in HepG2 cells[1].

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 24 hours
Result: Caused significantly enhanced cell viability as positive controls.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 10 μM
Incubation Time: 1 hour
Result: Decreased ethanol‐ induced iNOS protein expression.
Molecular Weight

464.38

Formula

C₂₁H₂₀O₁₂

CAS No.

482-35-9

SMILES

O=C1C(O[[email protected]]2[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]@H](CO)O2)O)O)O)=C(C3=CC=C(O)C(O)=C3)OC4=CC(O)=CC(O)=C14

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Quercetin 3-glucoside
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HY-N1445
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