2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. Aurantiamide acetate

Aurantiamide acetate  (Synonyms: Asperglaucide)

Cat. No.: HY-N2905 Purity: 99.24%
COA Handling Instructions

Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of  inflammatory diseases.

For research use only. We do not sell to patients.

Aurantiamide acetate Chemical Structure

Aurantiamide acetate Chemical Structure

CAS No. : 56121-42-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 352 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 352 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 320 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Aurantiamide acetate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of  inflammatory diseases[1][2].

IC50 & Target

cathepsin L

 

In Vitro

Aurantiamide acetate inhibits cathepsin L (3.4.22.15) and cathepsin B (3.4.22.1) with IC50 of 12 μM and 49 μM, respectiveiy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

444.52

Appearance

Solid

Formula

C27H28N2O4
CAS No.
SMILES

O=C(N[[email protected]](COC(C)=O)CC1=CC=CC=C1)[[email protected]@H](NC(C2=CC=CC=C2)=O)CC3=CC=CC=C3
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (112.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2496 mL 11.2481 mL 22.4962 mL
5 mM 0.4499 mL 2.2496 mL 4.4992 mL
10 mM 0.2250 mL 1.1248 mL 2.2496 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (5.62 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.62 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Aurantiamide56121-42-7AsperglaucideCathepsinadjuvant-arthriticcathepsin LPiper aurantiacuminflammatory diseasesInhibitorinhibitorinhibit

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