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Clodronate disodium tetrahydrate (Synonyms: Disodium clodronate tetrahydrate)

Cat. No.: HY-107794 Purity: >98.0%
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Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain.

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Clodronate disodium tetrahydrate Chemical Structure

Clodronate disodium tetrahydrate Chemical Structure

CAS No. : 88416-50-6

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Based on 1 publication(s) in Google Scholar

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Description

Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain[1][2].

IC50 & Target

vesicular ATP release[1]

In Vitro

Clodronate disodium tetrahydrate, a first-generation bisphosphonate, significantly attenuates neuropathic and inflammatory pain unrelated to bone abnormalities via inhibition of VNUT, a key molecule for the initiation of purinergic chemical transmission [1].
Clodronate disodium tetrahydrate is an allosteric modulator of VNUT Cl- dependence [1].
Clodronate disodium tetrahydrate acts as antiresorptive in osteoporosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition[1].
Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (22-30 g)[1]
Dosage: 10 mg/kg
Administration: Intravenous injection
Result: Attenuated carrageenan- or complete Freund’s adjuvant (CFA)-evoked inflammatory pain.
Clinical Trial
Molecular Weight

362.93

Formula

CH₁₂Cl₂Na₂O₁₀P₂

CAS No.

88416-50-6

SMILES

O=P(C(Cl)(Cl)P(O)(O[Na])=O)(O)O[Na].O.[4]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (344.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7554 mL 13.7768 mL 27.5535 mL
5 mM 0.5511 mL 2.7554 mL 5.5107 mL
10 mM 0.2755 mL 1.3777 mL 2.7554 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Clodronate disodium tetrahydrateDisodium clodronate tetrahydrateOthersClodronatepresynapticblockerneuropathicpainpurinergicsignalingvesicularnucleotidetransporterchemicaltransmissionanalgesicInhibitorinhibitorinhibit

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Clodronate disodium tetrahydrate
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