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Clodronate disodium tetrahydrate  (Synonyms: Disodium clodronate tetrahydrate)

Cat. No.: HY-107794 Purity: ≥98.0%
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Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain.

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Clodronate disodium tetrahydrate Chemical Structure

Clodronate disodium tetrahydrate Chemical Structure

CAS No. : 88416-50-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 33 In-stock
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10 mM * 1 mL in Water USD 33 In-stock
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100 mg USD 45 In-stock
250 mg USD 81 In-stock
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Based on 1 publication(s) in Google Scholar

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Clodronate disodium tetrahydrate Related Antibodies

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Description

Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain[1][2].

IC50 & Target

vesicular ATP release[1]
In Vitro

Clodronate disodium tetrahydrate, a first-generation bisphosphonate, significantly attenuates neuropathic and inflammatory pain unrelated to bone abnormalities via inhibition of VNUT, a key molecule for the initiation of purinergic chemical transmission [1].
Clodronate disodium tetrahydrate is an allosteric modulator of VNUT Cl- dependence [1].
Clodronate disodium tetrahydrate acts as antiresorptive in osteoporosis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clodronate disodium tetrahydrate Related Antibodies
In Vivo

Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition[1].
Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (22-30 g)[1]
Dosage: 10 mg/kg
Administration: Intravenous injection
Result: Attenuated carrageenan- or complete Freund’s adjuvant (CFA)-evoked inflammatory pain.
Clinical Trial
Molecular Weight

360.92

Formula

CH10Cl2Na2O10P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(C(Cl)(Cl)P(O)(O[Na])=O)(O)O[Na].O.O.O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (346.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7707 mL 13.8535 mL 27.7070 mL
5 mM 0.5541 mL 2.7707 mL 5.5414 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (69.27 mM); Clear solution; Need ultrasonic and warming

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7707 mL 13.8535 mL 27.7070 mL 69.2674 mL
5 mM 0.5541 mL 2.7707 mL 5.5414 mL 13.8535 mL
10 mM 0.2771 mL 1.3853 mL 2.7707 mL 6.9267 mL
15 mM 0.1847 mL 0.9236 mL 1.8471 mL 4.6178 mL
20 mM 0.1385 mL 0.6927 mL 1.3853 mL 3.4634 mL
25 mM 0.1108 mL 0.5541 mL 1.1083 mL 2.7707 mL
30 mM 0.0924 mL 0.4618 mL 0.9236 mL 2.3089 mL
40 mM 0.0693 mL 0.3463 mL 0.6927 mL 1.7317 mL
50 mM 0.0554 mL 0.2771 mL 0.5541 mL 1.3853 mL
60 mM 0.0462 mL 0.2309 mL 0.4618 mL 1.1545 mL
80 mM 0.0346 mL 0.1732 mL 0.3463 mL 0.8658 mL
100 mM 0.0277 mL 0.1385 mL 0.2771 mL 0.6927 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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