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Clodronic acid disodium salt (Synonyms: Clodronate disodium salt)

Cat. No.: HY-B0657A Purity: >99.0%
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Clodronic acid (Clodronate) disodium salt, a first-generation bisphosphonate, is orally active osteoclastic bone resorption inhibitor. Clodronic acid disodium salt can be used in high bone turnover states, Pagets disease and osteolytic bone metastases.

For research use only. We do not sell to patients.

Clodronic acid disodium salt Chemical Structure

Clodronic acid disodium salt Chemical Structure

CAS No. : 22560-50-5

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10 mM * 1  mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
50 mg USD 80 In-stock
Estimated Time of Arrival: December 31
100 mg USD 135 In-stock
Estimated Time of Arrival: December 31
250 mg USD 270 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Clodronic acid (Clodronate) disodium salt, a first-generation bisphosphonate, is orally active osteoclastic bone resorption inhibitor. Clodronic acid disodium salt can be used in high bone turnover states, Pagets disease and osteolytic bone metastases[1][2][3].

In Vitro

Clodronic acid (Clodronate) disodium salt induces rapid apoptosis in osteoclasts by preventing translocation of ADP into mitochondria after being internalised via resorption. Consequently, ATP production is inhibited, leading to induction of apoptosis by means of release of cytochrome C into the cytoplasm[2].

In Vivo

Clodronic acid (Clodronate) disodium salt (6.25-25 mg/kg; p.o.; daily for 28 days) slightly decreases the hindpaw swelling at doses of 12.5 and 25 mg/kg[3].

Animal Model: Male Lewis rats, aged 7 weeks[3]
Dosage: 6.25, 12.5, and 25 mg/kg
Administration: P.o.; daily for 28 days
Result: Hindpaw swelling was significantly smaller than in adjuvant-arthritis (AA)-control at 25 mg/kg on days 21 and 28 (87 and 88% of AA-control, respectively) and at 12.5 mg/kg on day 28.
Molecular Weight

288.86

Formula

CH₂Cl₂Na₂O₆P₂

CAS No.

22560-50-5

SMILES

O=P(C(Cl)(Cl)P(O)(O[Na])=O)(O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

Clodronic acid disodiumClodronate disodiumOthersfirst-generationosteoclasticboneresorptionPaget’smetastasesADPmitochondriacytochromeCInhibitorinhibitorinhibit

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Clodronic acid disodium salt
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