2. Apoptosis
  3. Apoptosis
  4. Clodronic acid

Clodronic acid (Clodronate) is an orally active bisphosphonate. Clodronic acid inhibits osteoclast-mediated bone resorption. Clodronic acid reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid is effective in the maintenance or improvement of bone mineral density. Clodronic acid can be used for the research of multiple myeloma and postmenopausal osteoporosis.

For research use only. We do not sell to patients.

Clodronic acid

Clodronic acid Chemical Structure

CAS No. : 10596-23-3

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10 mM * 1 mL in DMSO
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Based on 4 publication(s) in Google Scholar

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Clodronic acid Related Antibodies

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Description

Clodronic acid (Clodronate) is an orally active bisphosphonate. Clodronic acid inhibits osteoclast-mediated bone resorption. Clodronic acid reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid is effective in the maintenance or improvement of bone mineral density. Clodronic acid can be used for the research of multiple myeloma and postmenopausal osteoporosis[1][2][3].

In Vitro

Clodronic acid induces rapid apoptosis in osteoclasts by preventing translocation of ADP into mitochondria after being internalised via resorption. Consequently, ATP production is inhibited, leading to induction of apoptosis by means of release of cytochrome C into the cytoplasm[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clodronic acid Related Antibodies
In Vivo

Clodronic acid (6.25-25 mg/kg; p.o.; daily for 28 days) slightly decreases the hindpaw swelling at doses of 12.5 and 25 mg/kg[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Lewis rats, aged 7 weeks[3]
Dosage: 6.25, 12.5, and 25 mg/kg
Administration: P.o.; daily for 28 days
Result: Hindpaw swelling was significantly smaller than in adjuvant-arthritis (AA)-control at 25 mg/kg on days 21 and 28 (87 and 88% of AA-control, respectively) and at 12.5 mg/kg on day 28.
Clinical Trial
Molecular Weight

244.89

Formula

CH4Cl2O6P2
CAS No.
Appearance

Solid-Liquid Mixture

Color

Colorless to light yellow

SMILES

ClC(P(O)(O)=O)(Cl)P(O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (510.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0835 mL 20.4173 mL 40.8347 mL
5 mM 0.8167 mL 4.0835 mL 8.1669 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0835 mL 20.4173 mL 40.8347 mL 102.0867 mL
5 mM 0.8167 mL 4.0835 mL 8.1669 mL 20.4173 mL
10 mM 0.4083 mL 2.0417 mL 4.0835 mL 10.2087 mL
15 mM 0.2722 mL 1.3612 mL 2.7223 mL 6.8058 mL
20 mM 0.2042 mL 1.0209 mL 2.0417 mL 5.1043 mL
25 mM 0.1633 mL 0.8167 mL 1.6334 mL 4.0835 mL
30 mM 0.1361 mL 0.6806 mL 1.3612 mL 3.4029 mL
40 mM 0.1021 mL 0.5104 mL 1.0209 mL 2.5522 mL
50 mM 0.0817 mL 0.4083 mL 0.8167 mL 2.0417 mL
60 mM 0.0681 mL 0.3403 mL 0.6806 mL 1.7014 mL
80 mM 0.0510 mL 0.2552 mL 0.5104 mL 1.2761 mL
100 mM 0.0408 mL 0.2042 mL 0.4083 mL 1.0209 mL
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Clodronic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clodronic acid10596-23-3ClodronateApoptosisbone matrix growth-factorpostmenopausal osteoporosisosteoclastsmalignant osteolysismalignant bone diseasemultiple myelomametastatic prostate cancermacrophagesosteoclast-mediated bone resorptionosteoporotic postmenopausal womenInhibitorinhibitorinhibit

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