10596-23-3
10596-23-3
Chemical Structure
Clodronic acid
Synonym(s): Clodronate
- CAS No.: 10596-23-3
- Formula:CH4Cl2O6P2
- Molecular Weight:244.89
IUPAC Name: (dichloromethylene)bis(phosphonic acid)
InChIKey: ACSIXWWBWUQEHA-UHFFFAOYSA-N
SMILES: ClC(P(O)(O)=O)(Cl)P(O)(O)=O
Biological Activity: Clodronic acid (Clodronate) is an orally active bisphosphonate. Clodronic acid inhibits osteoclast-mediated bone resorption. Clodronic acid reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid is effective in the maintenance or improvement of bone mineral density. Clodronic acid can be used for the research of multiple myeloma and postmenopausal osteoporosis[1][2][3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Clodronic acid | 99.41% | Clodronic acid (Clodronate) is an orally active bisphosphonate. Clodronic acid inhibits osteoclast-mediated bone resorption. Clodronic acid reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid is effective in the maintenance or improvement of bone mineral density. Clodronic acid can be used for the research of multiple myeloma and postmenopausal osteoporosis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Medronic acid (Standard) | 99.87% | Medronic acid (Standard) is the analytical standard of Medronic acid. This product is intended for research and analytical applications. Medronic acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. Medronic acid can be used in bone imaging, while being complexed with radioisotopes. Due to its strong metal-chelating ability, Medronic acid can also be used as a water treatment chemical. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Hexane-1,6-diyldiphosphonic acid | Hexane-1,6-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Etidronic acid,60% in water (Standard) | ≥98% | Etidronic acid,60% in water (Standard) is the analytical standard of Etidronic acid,60% in water. This product is intended for research and analytical applications. Etidronic acid (Etidronate) is an orally and intravenously active bisphosphonate. Etidronic acid inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid has anticancer activity. Etidronic acid is a chelating agent and can be used to remove heavy metal in water. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Clodronic acid disodium salt | 100.50% | Clodronic acid (Clodronate) disodium salt is an orally active bisphosphonate. Clodronic acid disodium salt inhibits osteoclast-mediated bone resorption. Clodronic acid disodium salt reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid disodium salt is effective in the maintenance or improvement of bone mineral density. Clodronic acid disodium salt can be used for the research of multiple myeloma and postmenopausal osteoporosis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Ammonium dihydrogen phosphate | 99.2% | Ammonium dihydrogen phosphate is an ammonium phosphate salt with both hydrogenation and dehydration properties. Ammonium dihydrogen phosphate decomposes to form phosphoric acid and ammonia upon heating, and serves as a main component of fertilizers. Ammonium dihydrogen phosphate promotes glycosidic bond cleavage, formation of dehydrated sugars and furans, biomass carbonization, hydrogen donor reactions, and lignin bond weakening. Ammonium dihydrogen phosphate selectively promotes the production of furfural and levoglucosenone during the pyrolysis of lignocellulosic biomass. Ammonium dihydrogen phosphate can be used as a nitrogen/phosphorus source and activator for the preparation of nitrogen-phosphorus co-doped activated carbon. Ammonium dihydrogen phosphate acts as a sucrose conversion catalyst in sustainable wood adhesive formulations. Ammonium dihydrogen phosphate is applicable to related research in various fields such as agriculture and electronics. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Calcium pyrophosphate | 98.0% | Calcium pyrophosphate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Butane-1,4-diyldiphosphonic acid | 97.0% | Butane-1,4-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Sodium pyrophosphate decahydrate | 100.1% | Sodium pyrophosphate decahydrate is a phosphate donor and mild chelating agent. Sodium pyrophosphate decahydrate serves as a phosphate source for Pseudomonas aeruginosa acid phosphatase and its Q6 variant, enabling phosphorylation of L‑ascorbic acid to L‑ascorbate‑2‑phosphate. Sodium pyrophosphate decahydrate facilitates 99mTc labeling of human polyclonal IgG. Sodium pyrophosphate decahydrate can be used in research on musculoskeletal infections. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Etidronic acid,60% in water monohydrate | 98.0% | Etidronic acid,60% in water (Etidronate) monohydrate is a strong complexing agent that can be used as a chelating agent to remove heavy metals from water. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Tetrasodium pyrophosphate | 99.60% | Tetrasodium pyrophosphate is a water-soluble inorganic salt commonly used as a buffering agent, emulsifier, and sequestrant. Tetrasodium pyrophosphate is an antimicrobial agent that can reduce microbial colonization. Tetrasodium pyrophosphate blocks IPP translocation, enhances astaxanthin, phenol, flavonoid, and H2O2 levels, activates PAL and DPPH scavenging activity. Tetrasodium pyrophosphate can be used for the research of alleviating symptoms post COVID-19. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Morgan GJ, et al. First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Lancet. 2010;376(9757):1989-1999. [Content Brief]
- [2]. Tanakol R, et al. Clodronic acid in the treatment of postmenopausal osteoporosis. Clin Drug Investig. 2007;27(6):419-433. [Content Brief]
- [3]. Itoh F, et al. Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis. Inflammation. 2004 Feb;28(1):15-21. [Content Brief]
