22560-50-5
Chemical Structure
Clodronic acid disodium salt
Synonym(s): Clodronate disodium salt
- CAS 番号: 22560-50-5
- Formula:CH2Cl2Na2O6P2
- Molecular Weight:288.86
IUPAC Name: sodium (dichloromethylene)bis(hydrogen phosphonate)
InChIKey: HJKBJIYDJLVSAO-UHFFFAOYSA-L
SMILES: O=P(C(Cl)(Cl)P(O)(O[Na])=O)(O)O[Na]
Biological Activity: Clodronic acid (Clodronate) disodium salt is an orally active bisphosphonate. Clodronic acid disodium salt inhibits osteoclast-mediated bone resorption. Clodronic acid disodium salt reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid disodium salt is effective in the maintenance or improvement of bone mineral density. Clodronic acid disodium salt can be used for the research of multiple myeloma and postmenopausal osteoporosis[1][2][3].
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Clodronic acid disodium salt | 100.50% | Clodronic acid (Clodronate) disodium salt is an orally active bisphosphonate. Clodronic acid disodium salt inhibits osteoclast-mediated bone resorption. Clodronic acid disodium salt reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid disodium salt is effective in the maintenance or improvement of bone mineral density. Clodronic acid disodium salt can be used for the research of multiple myeloma and postmenopausal osteoporosis. | ||||||||||||||||||||
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Similarity Score 0.82
HY-B0302AREtidronic acid disodium (Standard) -
Similarity Score 0.78
HY-B0012APamidronate disodium -
Similarity Score 0.75
HY-B0657Clodronic acid -
Similarity Score 0.71
HY-16505Triclofos sodium -
Similarity Score 0.70
HY-B0012BPamidronic acid sodium -
Similarity Score 0.69
HY-W094517Sodium phosphate dibasic heptahydrate -
Similarity Score 0.69
HY-108685Alendronate sodium -
Similarity Score 0.65
HY-Y0308SPhosphate dibasic-d1 sodium -
Similarity Score 0.65
HY-W019972Calcium pyrophosphate -
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References
- [1]. Morgan GJ, et al. First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Lancet. 2010;376(9757):1989-1999. [Content Brief]
- [2]. Tanakol R, et al. Clodronic acid in the treatment of postmenopausal osteoporosis. Clin Drug Investig. 2007;27(6):419‐433. [Content Brief]
- [3]. Itoh F, et al. Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis. Inflammation. 2004 Feb;28(1):15-21. [Content Brief]
