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  4. Alendronate sodium

Alendronate sodium  (Synonyms: Alendronic acid monosodium salt)

Cat. No.: HY-108685 Purity: 98.0%
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Alendronate sodium is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate sodium induces skeletal alterations in the chicken embryonic development model. Alendronate sodium can be used for osteoporosis research.

For research use only. We do not sell to patients.

CAS No. : 129318-43-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of Alendronate sodium:

Alendronate sodium Related Antibodies

Top Publications Citing Use of Products

    Alendronate sodium purchased from MedChemExpress. Usage Cited in: J Med Chem. 2024 Sep 12;67(17):15738-15755.  [Abstract]

    Alendronate sodium hydrate (33 μM; 48 h) significantly restored mpx expression in Tg(drl:hoxa9) embryos.

    Alendronate sodium purchased from MedChemExpress. Usage Cited in: J Med Chem. 2024 Sep 12;67(17):15738-15755.  [Abstract]

    Alendronate sodium hydrate (33 μM; 48 h) recovered macrophage differentiation in Tg(drl:hoxa9) embryos.

    Alendronate sodium purchased from MedChemExpress. Usage Cited in: J Med Chem. 2024 Sep 12;67(17):15738-15755.  [Abstract]

    Flow cytometry analysis of CD14 and CD11b expression in U937 cells treated with different doses of Alendronate sodium hydrate (20-40 μM).

    Alendronate sodium purchased from MedChemExpress. Usage Cited in: J Med Chem. 2024 Sep 12;67(17):15738-15755.  [Abstract]

    Flow cytometry analysis of CD14 and CD11b expression in U937 cells treated with Alendronate sodium hydrate (30 μM; 3 d).

    Alendronate sodium purchased from MedChemExpress. Usage Cited in: J Med Chem. 2024 Sep 12;67(17):15738-15755.  [Abstract]

    Alendronate sodium hydrate (30 μM) induced chromatin condensation and increased the nucleocytoplasmic ratio in U937 cells, supporting the differentiation of these cells.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Alendronate sodium is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate sodium induces skeletal alterations in the chicken embryonic development model. Alendronate sodium can be used for osteoporosis research[1][2][3].

    Cellular Effect
    Cell Line Type Value Description References
    BMDM IC50
    0.39 μM
    Compound: ALN
    Anti-osteoclastogenic activity in M-CSF/RANKL-induced C57BL/6 mouse BMDM cells assessed as inhibition of M-CSF/RANKL-stimulated osteoclast differentiation measured after 5 days by TRAP staining based microscopic analysis
    Anti-osteoclastogenic activity in M-CSF/RANKL-induced C57BL/6 mouse BMDM cells assessed as inhibition of M-CSF/RANKL-stimulated osteoclast differentiation measured after 5 days by TRAP staining based microscopic analysis
    		[PMID: 39167391]
    BMDM IC50
    3.7 μM
    Compound: Alen
    Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-based microscopic analysis
    Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-based microscopic analysis
    		[PMID: 31257875]
    BMMC IC50
    1.71 μM
    Compound: Alendronate
    Anti-osteoporosis activity in C57BL/6 mouse BMM cells assessed as inhibition of M-CSF/RANKL-induced osteoclastogenesis by measuring reduction in multinucleated TRAP+ cells incubated for 5 days with media replenishment for every 48 hrs measured by TRAP-staining based analysis
    Anti-osteoporosis activity in C57BL/6 mouse BMM cells assessed as inhibition of M-CSF/RANKL-induced osteoclastogenesis by measuring reduction in multinucleated TRAP+ cells incubated for 5 days with media replenishment for every 48 hrs measured by TRAP-staining based analysis
    		[PMID: 33485256]
    RAW264.7 IC50
    0.084 μM
    Compound: AS
    Antiosteoclast activity in mouse RAW264.7 cells assessed as inhibition of RANKL-induced osteoclast differentiation after 5 days by TRAP assay
    Antiosteoclast activity in mouse RAW264.7 cells assessed as inhibition of RANKL-induced osteoclast differentiation after 5 days by TRAP assay
    		10.1039/C5MD00482A
    T-cell EC50
    0.75 μM
    Compound: Alendronate
    Mean effective concentration of compound was determined in stimulating Vgamma9 / Vdelta2 T cell
    Mean effective concentration of compound was determined in stimulating Vgamma9 / Vdelta2 T cell
    		[PMID: 12657258]
    T-cell EC50
    0.9 μM
    Compound: Alendronate
    Effective concentration range of compound was determined in stimulating Vgamma9 / Vdelta2 T cell
    Effective concentration range of compound was determined in stimulating Vgamma9 / Vdelta2 T cell
    		[PMID: 12657258]
    T-cell EC50
    1 μM
    Compound: Alendronate
    Effective concentration range of compound was determined in stimulating Vgamma9 / Vdelta2 T cell
    Effective concentration range of compound was determined in stimulating Vgamma9 / Vdelta2 T cell
    		[PMID: 12657258]
    In Vivo

    Alendronate (1.5E-10-1.5E-7 M, intra-air cell injection, single dose at embryonic day 7, exposure for 4 days) sodium induces skeletal alterations in the chicken embryonic development model[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Viable fertilized chick eggs (7 days)[3]
    Dosage: 1.5E-7 M, 1.5E-8 M, 1.5E-9 M, and 1.5E-10 M
    Administration: intra-air cell injection, single dose at embryonic day 7, exposure for 4 days
    Result: Showed an 87.5% viability rate and a 75% viability rate at 1.5E-10 M and other doses, respectively.
    Significantly reduced bone morphometric indexes (bone volume (BV) and bone surface (BS)) and cortical thickness in a dose-dependent manner.
    Significantly reduced dimensions and diminished mineralization in a concentration-dependent manner.
    Significantly increased TNFRSF11B, NF-κB1 and IL-6 levels, and decreased TNFRSF11A, CTSK, COL1A2, SPP1, and SOST levels, compared to control.
    Molecular Weight

    271.08

    Formula

    C4H12NNaO7P2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=P(O)(O)C(CCCN)(O)P(O)(O[Na])=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 25 mg/mL (92.22 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6889 mL 18.4447 mL 36.8895 mL
    5 mM 0.7378 mL 3.6889 mL 7.3779 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

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    Dosing volume
    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: ≥98.0%

    SDS (393 KB)

    COA (251 KB) HNMR (161 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.6889 mL 18.4447 mL 36.8895 mL 92.2237 mL
    5 mM 0.7378 mL 3.6889 mL 7.3779 mL 18.4447 mL
    10 mM 0.3689 mL 1.8445 mL 3.6889 mL 9.2224 mL
    15 mM 0.2459 mL 1.2296 mL 2.4593 mL 6.1482 mL
    20 mM 0.1844 mL 0.9222 mL 1.8445 mL 4.6112 mL
    25 mM 0.1476 mL 0.7378 mL 1.4756 mL 3.6889 mL
    30 mM 0.1230 mL 0.6148 mL 1.2296 mL 3.0741 mL
    40 mM 0.0922 mL 0.4611 mL 0.9222 mL 2.3056 mL
    50 mM 0.0738 mL 0.3689 mL 0.7378 mL 1.8445 mL
    60 mM 0.0615 mL 0.3074 mL 0.6148 mL 1.5371 mL
    80 mM 0.0461 mL 0.2306 mL 0.4611 mL 1.1528 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Alendronate sodium Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Alendronate129318-43-0Alendronic acid monosodiumNF-κBInterleukin RelatedNuclear factor-κBNuclear factor-kappaBILosteoporosisosteogenesisadipogenesisoralbisphosphonateInhibitorinhibitorinhibit

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