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Alendronic acid 

Cat. No.: HY-B0631 Purity: >98.0%
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Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease.

For research use only. We do not sell to patients.

Alendronic acid Chemical Structure

Alendronic acid Chemical Structure

CAS No. : 66376-36-1

Size Price Stock Quantity
10 mM * 1  mL in Water USD 94 In-stock
Estimated Time of Arrival: December 31
100 mg USD 85 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease[1].

In Vitro

Bisphosphonates are widely used in the treatment of osteoporosis, and among the bisphosphonates, alendronic acid is the most frequently prescribed drug. Bisphosphonates have powerful inhibitory effects on bone remodeling, a process that is critically important for fracture healing[2].

Molecular Weight

249.10

Formula

C₄H₁₃NO₇P₂

CAS No.

66376-36-1

SMILES

OC(P(O)(O)=O)(CCCN)P(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 8.33 mg/mL (33.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0145 mL 20.0723 mL 40.1445 mL
5 mM 0.8029 mL 4.0145 mL 8.0289 mL
10 mM 0.4014 mL 2.0072 mL 4.0145 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Keywords:

Alendronic acidOthersosteoporosisbisphosphonatesboneturnoverhealingFDPSInhibitorinhibitorinhibit

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Alendronic acid
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HY-B0631
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