Alendronate-d4
Alendronate-d4 (Alendronic acid-d4) is the deuterated-labeled Alendronate (HY-B0631). Alendronate is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate induces skeletal alterations in the chicken embryonic development model. Alendronate can be used for osteoporosis research.
For research use only. We do not sell to patients.
- CAS No.: 1309283-09-7
- Formula: C4H9D4NO7P2
- Molecular Weight:253.12
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 1309283-09-7
-
Unlabeled CAS 66376-36-1
-
Molecular Weight 253.12
-
Formula C4H9D4NO7P2
-
SMILES
O=P(O)(O)C(CC([2H])([2H])C([2H])([2H])N)(O)P(O)(O)=O
-
Synonyms
Alendronic acid-d4; MK 217-d4 free base; G-704650 Adronat-d4 free base
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Imai K. Alendronate sodium hydrate (oral jelly) for the treatment of osteoporosis: review of a novel, easy to swallow formulation. Clin Interv Aging. 2013;8:681-688. [Content Brief]
[2]. Sharpe M, et al. Alendronate: an update of its use in osteoporosis. Drugs. 2001;61(7):999-1039. [Content Brief]
[3]. de Campos WG, et al. Alendronate induces skeletal alterations in the chicken embryonic development model. Toxicol Appl Pharmacol. 2023 Oct 1;476:116673. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Alendronate-d4 Related Classifications
HY-108685S Related Classifications
Powered by Bioz