Cat. No.: HY-B0012A

Pamidronate disodium

(Synonyms: CGP 23339A)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Pamidronate disodium (CGP 23339A), the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 57248-88-1
Formula: C₃H₉NNa₂O₇P₂
Molecular Weight:279.03

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Pamidronate disodium Chemical Structure

CAS No.: 57248-88-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Wnt Isoforms :

All Toll-like Receptor (TLR) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
T-cell	EC₅₀	2.21 μM Compound: Pamidronate	Mean effective concentration of compound was determined in stimulating Vgamma9 / Vdelta2 T cell Mean effective concentration of compound was determined in stimulating Vgamma9 / Vdelta2 T cell	[PMID: 12657258]

In Vitro

Pamidronate disodium (0.001-1000 µM, 72 h) inhibits the cell viability of osteosarcoma cells POS, HMPOS and COS31, exhibits no cytotoxicity to fibroblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

POS, HMPOS and COS31
Concentration:

0.001-1000 µM
Incubation Time:

72 h
Result:

Inhibited the cell viability.

In Vivo

Pamidronate disodium (3 mg/kg, ear vein injection, once monthly for 14 weeks) improves the bone structure, alleviates the degenerative changes of cartilage, exhibits protective effect against osteoarthritis in rabbit models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Anterior cruciate ligament transection (ACLT)-induced osteoarthritis in rabbits^[3]
Dosage:

3 mg/kg
Administration:

ear vein injection, once monthly for 14 weeks
Result:

Increased bone volume fraction (BV/TV), trabecular thickness (TbTh) and trabecular number (TbN).
Reduced the erosion of cartilage surface, increase the content of chondrocytes and matrix.

Chemical Information

CAS No. 57248-88-1
Appearance Solid
Molecular Weight 279.03
Formula C₃H₉NNa₂O₇P₂
Color White to off-white
SMILES

OP(C(O)(P(O)(O[Na])=O)CCN)(O[Na])=O
Synonyms

CGP 23339A
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Cell Rep Methods

RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]

2023 Oct 23;3(10):100599. PMID: 37797618

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (179.19 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5838 mL

17.9192 mL

35.8384 mL

5 mM

0.7168 mL

3.5838 mL

7.1677 mL

10 mM

0.3584 mL

1.7919 mL

3.5838 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ashton JA, et al. Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cellsfrom dogs. Am J Vet Res. 2005 May;66(5):885-91. [Content Brief]

[2]. Xu Y, et al. Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro. J Oral Maxillofac Surg. 2017 Mar 22. [Content Brief]

[3]. Lv Y, et al. Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits. BMC Musculoskelet Disord. 2014 Nov 6;15:370. [Content Brief]

[4]. Kovacs R, et al. The synthesis of pamidronic derivatives in different solvents: An optimization and a mechanistic study[J]. Heteroatom Chemistry, 2014, 25(3): 186-193.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	3.5838 mL	17.9192 mL	35.8384 mL	89.5961 mL
	5 mM	0.7168 mL	3.5838 mL	7.1677 mL	17.9192 mL
	10 mM	0.3584 mL	1.7919 mL	3.5838 mL	8.9596 mL
	15 mM	0.2389 mL	1.1946 mL	2.3892 mL	5.9731 mL
	20 mM	0.1792 mL	0.8960 mL	1.7919 mL	4.4798 mL
	25 mM	0.1434 mL	0.7168 mL	1.4335 mL	3.5838 mL
	30 mM	0.1195 mL	0.5973 mL	1.1946 mL	2.9865 mL
	40 mM	0.0896 mL	0.4480 mL	0.8960 mL	2.2399 mL
	50 mM	0.0717 mL	0.3584 mL	0.7168 mL	1.7919 mL
	60 mM	0.0597 mL	0.2987 mL	0.5973 mL	1.4933 mL
	80 mM	0.0448 mL	0.2240 mL	0.4480 mL	1.1200 mL
	100 mM	0.0358 mL	0.1792 mL	0.3584 mL	0.8960 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Pamidronate disodium

1 Cited Publications

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Pamidronate disodium

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Publications Citing Use of MedChemExpress (MCE) Pamidronate disodium

All Wnt Isoforms

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Pamidronate disodium Related Classifications

HY-B0012A Related Classifications