2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TNF Superfamily
  5. TNF Receptor Superfamily
  6. Osteoprotegerin

Osteoprotegerin

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Osteoprotegerin (OPG) belongs to TNF receptor superfamily. OPG is expressed in many tissues besides osteoblasts, including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin plays a critical role in bone remodeling, and has osteoprotective effect. Osteoprotegerin also protects large blood vessels from medial calcification. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis[1]. OPG is also involved in multiple processes of cancers, such as tumor survival, epithelial to mesenchymal transition (EMT), neo-angiogenesis, invasion, and metastasis. Human osteoprotegerin shares <85% aa sequence identity with mouse and rat. Mouse OX40 shares 94.5% aa sequence identity with rat.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70805
    TNFRSF11B/OPG Protein, Human (HEK293, His)

    Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis Inhibitory Factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG

    		Human HEK293
    Osteoprotegerin (OPG), a TNF receptor superfamily, is expressed in many tissues including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin has osteoprotective effect and is critical in bone remodeling. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis. OPG is also involved in multiple biological processes of cancers. TNFRSF11B/OPG Protein, Human (HEK293, His) is a recombinant human TNFRSF11B/OPG (E22-L401) with C-terminal 6*His tag, which is produced in HEK293 cell.
  • HY-P71017
    TNFRSF11B/OPG Protein, Mouse (HEK293, His)

    Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; Tnfrsf11b; Ocif; Opg

    		Mouse HEK293
    Osteoprotegerin (OPG), a TNF receptor superfamily, is expressed in many tissues including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin has osteoprotective effect and is critical in bone remodeling. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis. OPG is also involved in multiple biological processes of cancers. TNFRSF11B/OPG Protein, Mouse (HEK293, His) is a recombinant mouse TNFRSF11B/OPG (E22-L401) with C-terminal 10*His tag, which is produced in HEK293 cell.
  • HY-P73332
    TNFRSF11B/OPG Protein, Human (HEK293, His, solution)

    OPG; Tumor necrosis factor receptor superfamily member 11B; TNFRSF11B; OCIF

    		Human HEK293
    Osteoprotegerin (OPG), a TNF receptor superfamily, is expressed in many tissues including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin has osteoprotective effect and is critical in bone remodeling. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis. OPG is also involved in multiple biological processes of cancers. TNFRSF11B/OPG Protein, Human (HEK293, His, solution) is a recombinant human TNFRSF11B/OPG (E22-L401) with C-terminal His tag, which is produced in HEK293 cell.
  • HY-P7053
    TNFRSF11B/OPG Protein, Human (CHO, Fc)

    rHuOPG; Tumor necrosis factor receptor superfamily member 11B; TNFRSF11B; OCIF

    		Human CHO
    Osteoprotegerin (OPG), a TNF receptor superfamily, is expressed in many tissues including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin has osteoprotective effect and is critical in bone remodeling. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis. OPG is also involved in multiple biological processes of cancers. TNFRSF11B/OPG Protein, Human (CHO, Fc) is a recombinant human TNFRSF11B/OPG (E22-L201) with C-terminal hFc tag, which is produced in CHO cell.
  • HY-P74661
    TNFRSF11B/OPG Protein, Rhesus Macaque (hFc)

    OCIF; OPG; OPGtumor necrosis factor receptor superfamily member 11B

    		Rhesus Macaque HEK293
    Osteoprotegerin (OPG), a TNF receptor superfamily, is expressed in many tissues including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin has osteoprotective effect and is critical in bone remodeling. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis. OPG is also involved in multiple biological processes of cancers. TNFRSF11B/OPG Protein, Rhesus Macaque (hFc) is a recombinant Rhesus Macaque TNFRSF11B/OPG (M28-L428) with C-terminal hFc tag, which is produced in HEK293 cell.
  • HY-P700432
    TNFRSF11B/OPG Protein, Human (HEK293, hFc-Flag)

    Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis Inhibitory Factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG

    		Human HEK293
    TNFRSF11B/OPG functions as a decoy receptor for TNFSF11/RANKL, neutralizing its osteoclastogenic effects and promoting osteoclast apoptosis in vitro. Crucial for bone homeostasis, it modulates the TNFSF11/TNFRSF11B ratio. Additionally, TNFRSF11B may prevent arterial calcification, acting as a decoy receptor for TNFSF10/TRAIL to inhibit apoptosis. The homodimeric structure enables TNFRSF11B to interact with TNFSF10 and TNFSF11, regulating essential pathways in bone metabolism and cellular survival. TNFRSF11B/OPG Protein, Human (HEK293, hFc-Flag) is the recombinant human-derived TNFRSF11B/OPG protein, expressed by HEK293, with C-hFc, C-Flag labeled tag. The total length of TNFRSF11B/OPG Protein, Human (HEK293, hFc-Flag) is 380 a.a., with molecular weight of 73.5 kDa.
Cat. No. Product Name Effect Purity