1. GPCR/G Protein
  2. Ras
  3. AMG-510

AMG-510 

Cat. No.: HY-114277 Purity: 99.01%
Handling Instructions

AMG-510 is a potent KRAS G12C covalent inhibitor.

For research use only. We do not sell to patients.

AMG-510 Chemical Structure

AMG-510 Chemical Structure

Size Stock
250 mg Get quote
500 mg Get quote

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Description

AMG-510 is a potent KRAS G12C covalent inhibitor[1].

IC50 & Target

KRAS G12C[1]

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (222.98 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7838 mL 8.9192 mL 17.8383 mL
5 mM 0.3568 mL 1.7838 mL 3.5677 mL
10 mM 0.1784 mL 0.8919 mL 1.7838 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.71 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

560.59

Formula

C₃₀H₃₀F₂N₆O₃

SMILES

O=C(C=C)N1C[[email protected]](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
AMG-510
Cat. No.:
HY-114277
Quantity:

AMG-510

Cat. No.: HY-114277