2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras p38 MAPK
  4. Sotorasib racemate

Sotorasib racemate  (Synonyms: AMG-510 racemate)

Cat. No.: HY-114277A Purity: 98.99%
COA Handling Instructions

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Sotorasib racemate (Compound A) is an orally active racemate of Sotorasib (HY-114277), a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer and can be applied to cancer research.

For research use only. We do not sell to patients.

Sotorasib racemate Chemical Structure

Sotorasib racemate Chemical Structure

CAS No. : 2252403-56-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Sotorasib racemate:

Sotorasib racemate Related Antibodies

Top Publications Citing Use of Products

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K-Ras H-Ras Ras

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Sotorasib racemate (Compound A) is an orally active racemate of Sotorasib (HY-114277), a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer and can be applied to cancer research[1].

IC50 & Target[1]

KRas G12C

 

In Vivo

Sotorasib racemate (30-100 mg/kg, p.o., QD for 21 d) suppresses NCI-H358 tumor growth in a dose-dependent manner in tumor xenograft mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/SCID mice, tumor xenograft model of NCI-H358 cells which harbor KRAS G12C (human NSCLC cell)[1]
Dosage: 10, 30, 100 mg/kg
Administration: Oral gavage (p.o.), QD for 21 d
Result: Suppressed the growth of the NCI-H358 tumors in a dose-dependent manner, observed significant tumor regression at 100 mg/kg and 30 mg/kg with tumor growth inhibition of 137% and 126%, respectively.
Molecular Weight

560.59

Formula

C30H30F2N6O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C2=C(C)C=CN=C2C(C)C)C3=NC(C4=C(O)C=CC=C4F)=C(F)C=C3C(N5[C@@H](C)CN(C(C=C)=O)CC5)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 3.85 mg/mL (6.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7838 mL 8.9192 mL 17.8383 mL
5 mM 0.3568 mL 1.7838 mL 3.5677 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.99%

COA (257 KB) HNMR (216 KB) RP-HPLC (109 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7838 mL 8.9192 mL 17.8383 mL 44.5959 mL
5 mM 0.3568 mL 1.7838 mL 3.5677 mL 8.9192 mL
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Sotorasib racemate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sotorasib2252403-56-6AMG-510AMG510AMG 510Rasp38 MAPKNSCLCKRAS G12CinhibitorNOD/SCID miceNCI-H358 cellInhibitorinhibit

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