Sotorasib racemate
Based on 1 publication(s) in Google Scholar
Sotorasib racemate (Compound A) is an orally active racemate of Sotorasib (HY-114277), a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer and can be applied to cancer research.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.99%
- CAS No.: 2252403-56-6
- 화학식: C30H30F2N6O3
- 분자량:560.59
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보관:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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HY-130149
AdagrasibKRAS G12C Inhibitor -
HY-153724
BI-2865Pan-KRAS Inhibitor -
HY-134813
MRTX1133KRAS G12D Inhibitor -
HY-145928
DivarasibKRAS G12C Inhibitor -
HY-148439
DaraxonrasibRAS(ON) Inhibitor -
HY-114277
SotorasibKRAS G12C Inhibitor -
HY-U00418
ARS-1620 -
HY-10261
AfatinibEGFR/HER2 Inhibitor -
HY-112089
NaporafenibB/CRAF Inhibitor -
HY-114277R
Sotorasib (Standard)KRAS G12C Inhibitor -
HY-114436
MRTX-1257KRAS G12C Inhibitor -
HY-18674
K-Ras-IN-1K-Ras Inhibitor
Publications Citing Use of MedChemExpress (MCE) Sotorasib racemate
More
Biological Activity
제품 설명
IC50 & Target
[1]|
KRas G12C |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female NOD/SCID mice, tumor xenograft model of NCI-H358 cells which harbor KRAS G12C (human NSCLC cell)[1]
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Dosage:10, 30, 100 mg/kg
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Administration:Oral gavage (p.o.), QD for 21 d
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Result:Suppressed the growth of the NCI-H358 tumors in a dose-dependent manner, observed significant tumor regression at 100 mg/kg and 30 mg/kg with tumor growth inhibition of 137% and 126%, respectively.
Chemical Information
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CAS No. 2252403-56-6
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Appearance Solid
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분자량 560.59
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화학식 C30H30F2N6O3
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Color Light yellow to yellow
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SMILES
O=C1N(C2=C(C)C=CN=C2C(C)C)C3=NC(C4=C(O)C=CC=C4F)=C(F)C=C3C(N5[C@@H](C)CN(C(C=C)=O)CC5)=N1
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Synonyms
AMG-510 racemate
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Ther
RAC1 directly phosphorylates both PKM2 and FBP1 to promote radioresistance in hepatocellular carcinoma. [Abstract]2025 Nov 7:S1525-0016(25)00870-6. PMID: 41204670
용액&용해도
In Vitro:
DMSO : 3.85 mg/mL (6.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7838 mL | 8.9192 mL | 17.8383 mL | 44.5959 mL |
| 5 mM | 0.3568 mL | 1.7838 mL | 3.5677 mL | 8.9192 mL |
Sotorasib racemate Related Classifications
HY-114277A Related Classifications
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