1. Membrane Transporter/Ion Channel
    Autophagy
  2. Potassium Channel
    Autophagy
    CFTR
    P-glycoprotein
  3. Glibenclamide

Glibenclamide (Synonyms: Glyburide)

Cat. No.: HY-15206 Purity: 99.79%
Handling Instructions

Glibenclamide is a high affinity P-glycoprotein inhibitor and appears to be general inhibitor of ABC transporters. Glibenclamide binds to the sulphonylurea receptor (SUR) and to the cystic fibrosis transmembrane conductance regulator proteins (CFTR) and blocks their function. Glibenclamide is a potent second-generation sulfonylurea agent that improves glucose control by acting both on insulin secretion and on insulin action..

For research use only. We do not sell to patients.

Glibenclamide Chemical Structure

Glibenclamide Chemical Structure

CAS No. : 10238-21-8

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 8 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Glibenclamide purchased from MCE. Usage Cited in: Front Cell Dev Biol. 2020 May 12;8:269.

    The inhibition of HSP70 releasing by Glibenclamide suppresses morphine-induced ER stress and the phosphorylation of PKA and NR-1. Glibenclamide (200 μM) inhibits the decrease of intracellular HSP70 caused by morphine in SH-SY5Y cells.
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    Description

    Glibenclamide is a high affinity P-glycoprotein inhibitor and appears to be general inhibitor of ABC transporters. Glibenclamide binds to the sulphonylurea receptor (SUR) and to the cystic fibrosis transmembrane conductance regulator proteins (CFTR) and blocks their function. Glibenclamide is a potent second-generation sulfonylurea agent that improves glucose control by acting both on insulin secretion and on insulin action[1][2]..

    IC50 & Target

    P-glycoprotein[1]

    In Vitro

    Glibenclamide increases [3H]colchicine accumulation in VBL600 cells, CC531mdr+ cells and OK cells except CEM cells. Glibenclamide is a substrate of P-glycoprotein. Glibenclamide inhibits P-glycoprotein and appears to be general inhibitor of ABC transporters[1].
    Glibenclamide has a mixed effect on the ischemic myocardium. Glibenclamide inhibits K+ channels in the brain[2].
    Glibenclamide-induced autophagy inhibits its insulin secretion-improving function in β Cells[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Glibenclamide stimulates tissue glucose disposal during a hyperglycemic challenge[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    494.00

    Formula

    C₂₃H₂₈ClN₃O₅S

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 250 mg/mL (506.07 mM; Need ultrasonic)

    H2O : 0.1 mg/mL (0.20 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0243 mL 10.1215 mL 20.2429 mL
    5 mM 0.4049 mL 2.0243 mL 4.0486 mL
    10 mM 0.2024 mL 1.0121 mL 2.0243 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Product Name:
    Glibenclamide
    Cat. No.:
    HY-15206
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