1. Immunology/Inflammation
    PI3K/Akt/mTOR
    NF-κB
  2. Toll-like Receptor (TLR)
    PI3K
    Akt
    NF-κB
  3. Polygalasaponin F

Polygalasaponin F 

Cat. No.: HY-N0392 Purity: >99.0%
Handling Instructions

Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secretion through the regulation of the TLR4-PI3K/AKT-NF-kB signaling pathway .

For research use only. We do not sell to patients.

Polygalasaponin F Chemical Structure

Polygalasaponin F Chemical Structure

CAS No. : 882664-74-6

Size Price Stock Quantity
5 mg USD 202 In-stock
Estimated Time of Arrival: December 31
10 mg USD 343 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1030 Get quote
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secretion through the regulation of the TLR4-PI3K/AKT-NF-kB signaling pathway [1].

IC50 & Target

TLR4

 

PI3K

 

Akt

 

NF-κB

 

Molecular Weight

1091.24

Formula

C₅₃H₈₆O₂₃

CAS No.

882664-74-6

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (91.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9164 mL 4.5819 mL 9.1639 mL
5 mM 0.1833 mL 0.9164 mL 1.8328 mL
10 mM 0.0916 mL 0.4582 mL 0.9164 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.29 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Polygalasaponin FToll-like Receptor (TLR)PI3KAktNF-κBPhosphoinositide 3-kinasePKBProtein kinase BNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Product Name:
Polygalasaponin F
Cat. No.:
HY-N0392
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