Sedanolide 

Sedanolide, a natural compound occurring in edible umbelliferous plants, possesses anti-inflammatory and antioxidant activities^[1][2].

Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sedanolide increases the activity of glutathione-S-transferase (GST) in the liver, small intestinal mucosa, and forestomach of A/J mice^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

194.27

Solid

C₁₂H₁₈O₂

6415-59-4

O=C1OC(CCCC)C2CCCC=C21

Room temperature in continental US; may vary elsewhere.

• [1]. J A Woods, et al. Sedanolide, a Natural Phthalide From Celery Seed Oil: Effect on Hydrogen Peroxide and Tert-Butyl Hydroperoxide-Induced Toxicity in HepG2 and CaCo-2 Human Cell Lines. In Vitr Mol Toxicol. Fall 2001;14(3):233-40.  [Content Brief]

  [2]. Shu-Ling Hsieh, et al. Sedanolide Induces Autophagy Through the PI3K, p53 and NF-κB Signaling Pathways in Human Liver Cancer Cells. Int J Oncol. 2015 Dec;47(6):2240-6.  [Content Brief]