Dapsone-d₈  (Synonyms: 4,4′-Diaminodiphenyl sulfone-d₈; DDS-d₈)

Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].

Dapsone (0.06 mM; 30 min) suppresses intra- and extracellular production of superoxide (O₂^-) and elastase release triggered by N-Formyl-Met-Leu-Phe (HY-P0224) (1 μM) and physiological agonist C5a (100 nM), but not by Phorbol 12-myristate 13-acetate (HY-18739) (100 nM)^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dapsone (5 mg/kg; i.p.; single dose) shows neuroprotective effects and substantially improves memory acquisition in Scopolamine (HY-N0296)-induced memory impairment in mice^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

256.35

C₁₂H₄D₈N₂O₂S

557794-38-4

Solid

White to off-white

NC1=C(C([2H])=C(C([2H])=C1[2H])S(C2=C(C([2H])=C(C([2H])=C2[2H])N)[2H])(=O)=O)[2H]

Room temperature in continental US; may vary elsewhere.

• [1]. Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol  [Content Brief]

  [2]. Dapsone. Drug.com

  [3]. D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9.  [Content Brief]

  [4]. Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607.  [Content Brief]

  [5]. Wozel G, et al. Dapsone in dermatology and beyond. Arch Dermatol Res. 2014 Mar;306(2):103-24.  [Content Brief]

  [6]. Noroozi N, et al. Protective Effects of Dapsone on Scopolamine-Induced Memory Impairment in Mice: Involvement of Nitric Oxide Pathway. Dement Geriatr Cogn Dis Extra. 2022 Mar 24;12(1):43-50.  [Content Brief]