1. Anti-infection
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
  2. Bacterial
    Reactive Oxygen Species
  3. Dapsone

Dapsone (Synonyms: 4,4′-Diaminodiphenyl sulfone; DDS)

Cat. No.: HY-B0688 Purity: 99.15%
Handling Instructions

Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.

For research use only. We do not sell to patients.

Dapsone Chemical Structure

Dapsone Chemical Structure

CAS No. : 80-08-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 96 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Description

Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Target: Antibacterial Dapsone is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). Dapsone antagonized all of the I/R end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, antiinflammatory, and anti-apoptotic effects [1]. As an antibacterial, dapsone inhibits bacterial synthesis of dihydrofolic acid, via competition with para-aminobenzoate for the active site of dihydropteroate synthetase. Dapsone has anti-inflammatory and immunomodulatory effects [2].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (136.93 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0274 mL 20.1369 mL 40.2739 mL
5 mM 0.8055 mL 4.0274 mL 8.0548 mL
10 mM 0.4027 mL 2.0137 mL 4.0274 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

248.30

Formula

C₁₂H₁₂N₂O₂S

CAS No.

80-08-0

SMILES

O=S(C1=CC=C(N)C=C1)(C2=CC=C(N)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Dapsone
Cat. No.:
HY-B0688
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Dapsone

Cat. No.: HY-B0688