1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    PI3K/Akt/mTOR
    Stem Cell/Wnt
  2. Calcium Channel
    GSK-3
  3. Cromolyn sodium

Cromolyn sodium (Synonyms: Disodium Cromoglycate; FPL-670)

Cat. No.: HY-B0320A Purity: 99.97%
Handling Instructions

Cromolyn sodium is an antiallergic drug. Cromolyn sodium is a GSK-3β inhibitor with an IC50 of 2.0 µM.

For research use only. We do not sell to patients.

Cromolyn sodium Chemical Structure

Cromolyn sodium Chemical Structure

CAS No. : 15826-37-6

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10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
5 g USD 96 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Cromolyn sodium

    Cromolyn sodium purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160.

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.

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    Description

    Cromolyn sodium is an antiallergic drug. Cromolyn sodium is a GSK-3β inhibitor with an IC50 of 2.0 µM.

    IC50 & Target

    GSK-3β

    2 μM (IC50)

    In Vitro

    Cromolyn (sodium) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

    In Vivo

    Pretreatment of IIR mice with Cromolyn (sodium) prior to ischemia exhibited no changes of ET-1 levels, injury score and inflammation (P>0.05, PreCr vs. M groups). In conclusion, administration of Cromolyn (sodium) after reperfusion, but not prior to ischemia, attenuates IIRI by downregulating ET-1 and suppressing sustained MC activation[1]. Cromolyn (sodium) has a role in the prevention of Chronic lung disease(CLD). Cromolyn (sodium) cannot be recommended for the prevention of CLD in preterm infants[2].

    Clinical Trial
    Molecular Weight

    512.33

    Formula

    C₂₃H₁₄Na₂O₁₁

    CAS No.

    15826-37-6

    SMILES

    OC(COC1=C2C(C=C(C([O-])=O)OC2=CC=C1)=O)COC3=C4C(C=C(C([O-])=O)OC4=CC=C3)=O.[Na+].[Na+]

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 32 mg/mL (62.46 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9519 mL 9.7593 mL 19.5187 mL
    5 mM 0.3904 mL 1.9519 mL 3.9037 mL
    10 mM 0.1952 mL 0.9759 mL 1.9519 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Cromolyn sodium is dissolved in PBS[3].

    References
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    Cromolyn sodium
    Cat. No.:
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