1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    PI3K/Akt/mTOR
    Stem Cell/Wnt
  2. Calcium Channel
    GSK-3
  3. Cromolyn sodium

Cromolyn sodium (Synonyms: Disodium Cromoglycate; FPL-670)

Cat. No.: HY-B0320A Purity: 99.10%
Handling Instructions

Cromolyn sodium (Disodium Cromoglycate; FPL-670) is an antiallergic drug. Cromolyn sodium is a GSK-3β inhibitor with an IC50 of 2.0 µM.

For research use only. We do not sell to patients.

Cromolyn sodium Chemical Structure

Cromolyn sodium Chemical Structure

CAS No. : 15826-37-6

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Cromolyn sodium

    Cromolyn sodium purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160.

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.

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    Description

    Cromolyn sodium (Disodium Cromoglycate; FPL-670) is an antiallergic drug. Cromolyn sodium is a GSK-3β inhibitor with an IC50 of 2.0 µM.

    IC50 & Target

    GSK-3β

    2 μM (IC50)

    In Vitro

    Cromolyn sodium (Disodium Cromoglycate; FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Pretreatment of IIR mice with Cromolyn sodium (Disodium Cromoglycate; FPL-670) prior to ischemia exhibited no changes of ET-1 levels, injury score and inflammation (P>0.05, PreCr vs. M groups). In conclusion, administration of Cromolyn (sodium) after reperfusion, but not prior to ischemia, attenuates IIRI by downregulating ET-1 and suppressing sustained MC activation[1]. Cromolyn (sodium) has a role in the prevention of Chronic lung disease(CLD). Cromolyn (sodium) cannot be recommended for the prevention of CLD in preterm infants[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    512.33

    Formula

    C₂₃H₁₄Na₂O₁₁

    CAS No.

    15826-37-6

    SMILES

    OC(COC1=C2C(C=C(C(O[Na])=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(O[Na])=O)OC4=CC=C3)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (97.59 mM; Need ultrasonic)

    DMSO : 25 mg/mL (48.80 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9519 mL 9.7593 mL 19.5187 mL
    5 mM 0.3904 mL 1.9519 mL 3.9037 mL
    10 mM 0.1952 mL 0.9759 mL 1.9519 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution

    • 3.

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (97.59 mM); Clear solution; Need ultrasonic

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.10%

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    Keywords:

    CromolynDisodium Cromoglycate FPL-670FPL670FPL 670FPL-670Calcium ChannelGSK-3Ca2+ channelsCa channelsGlycogen synthase kinase-3Glycogen synthase kinase 3Inhibitorinhibitorinhibit

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    Product Name:
    Cromolyn sodium
    Cat. No.:
    HY-B0320A
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