Tricin from a malagasy connaraceous plant with potent antihistaminic activity

  • J Nat Prod. 2003 Sep;66(9):1273-5. doi: 10.1021/np030020p.
Hidenori Kuwabara  1 ,  Kyoko Mouri ,  Hideaki Otsuka ,  Ryoji Kasai ,  Kazuo Yamasaki
Affiliations
  • 1. Department of Pharmacognosy, Division of Medicinal Chemistry, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
PMID: 14510616 DOI: 10.1021/np030020p
Abstract

The bioassay-guided separation of a Malagasy plant, Agelaea pentagyna, led to the isolation of a flavonoid, tricin (1), with potent inhibitory activity toward exocytosis from antigen-stimulated rat leukemia basophils (RBL-2H3). The structure-activity relationships among structurally related natural and synthetic Flavonoids are also discussed.