1. Membrane Transporter/Ion Channel Neuronal Signaling Autophagy
  2. Calcium Channel Autophagy
  3. Dantrolene

Dantrolene  (Synonyms: F 368)

Cat. No.: HY-12542 Purity: ≥98.0%
COA Handling Instructions

Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene is a direct-acting skeletal muscle relaxant. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.

For research use only. We do not sell to patients.

Dantrolene Chemical Structure

Dantrolene Chemical Structure

CAS No. : 7261-97-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 72 In-stock
Solution
10 mM * 1 mL in DMSO USD 72 In-stock
Solid
5 mg USD 65 In-stock
10 mg USD 92 In-stock
25 mg USD 130 In-stock
50 mg USD 210 In-stock
100 mg USD 270 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Dantrolene:

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  • Biological Activity

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Description

Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene is a direct-acting skeletal muscle relaxant. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome[1][2][3].

In Vitro

Dantrolene (60 μM; at 1 and 3 days) significantly inhibits ACTA2 expression and upregulats RUNX2 expression in paVICs[2].
Dantrolene (60 μM; overnight pretreatment) inhibits LPC-induced calcium flux in porcine aortic valve interstitial cells[2].
Dantrolene (10, 30, 60 μM) inhibited calcific nodule formation of paVICs due to 10 μM lysophosphatidylcholine (LPC)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[2]

Cell Line: Porcine aortic valvular interstitial cells (paVICs)
Concentration: 60 μM
Incubation Time: At 1 and 3 days
Result: Significantly inhibited ACTA2 expression and upregulated RUNX2 expression.
In Vivo

Dantrolene (5 mg/kg; fed orally twice per week) improves performance in the beam-walking and gait-walking assay[3].
Dantrolene (10 mg/kg; IP; three days per week; for 40-60 days) significantly improves gait, reduces LC3-II levels, improves mitochondrial ATP production and reduced inflammation in the brain. Dantrolene partially reduces autophagy and the expression of CALM (calmodulin) in the brain of neuronopathic Gaucher disease mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: YAC128 transgenic mice (FVBN/NJ background strain) and WT mice[3]
Dosage: 5 mg/kg
Administration: Fed orally twice per week from 2 to 11.5 months of age
Result: Resulted in significantly improved performance in the beam-walking and gait-walking assays.
Significantly reduced the loss of NeuN-positive striatal neurons and reduced formation of Httexp nuclear aggregates.
Clinical Trial
Molecular Weight

314.25

Formula

C14H10N4O5

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC(CN1/N=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (63.64 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1822 mL 15.9109 mL 31.8218 mL
5 mM 0.6364 mL 3.1822 mL 6.3644 mL
10 mM 0.3182 mL 1.5911 mL 3.1822 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Dantrolene is suspended in 50 μL of PBS with 2% corn flour[5].

Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dantrolene
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