1. Anti-infection
  2. Bacterial
  3. Sulfanilamide

Sulfanilamide (Synonyms: Sulphanilamide)

Cat. No.: HY-B0242 Purity: 99.89%
Handling Instructions

Sulfanilamide is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.

For research use only. We do not sell to patients.

Sulfanilamide Chemical Structure

Sulfanilamide Chemical Structure

CAS No. : 63-74-1

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 g USD 50 In-stock
Estimated Time of Arrival: December 31
10 g USD 70 In-stock
Estimated Time of Arrival: December 31
50 g   Get quote  

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Sulfanilamide is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM. Target: dihydropteroate synthetase; Antibacterial Sulfanilamide containing the sulfonamide functional group displays inhibitory activity for dihydropteroate synthetase partially purified from Escherichia coli which normally uses para-aminobenzoic acid (PABA) for synthesizing the necessary folic acid acting as a coenzyme in the synthesis of purine, pyrimidine and other amino acids, exhibiting an IC 50 of 320 μM for dihydropteroate synthetasea and Km of 2.5 uM for PABA [1]. Sulfanilamide shows IC50 of 286.8 μg/mL for recombinant S. cerevisiae strains with wild-type FOL1 genes, but the single mutation 55Trp to 55Ala or 57Pro to 57Ser within the putative active site of the fungal DHPS confers resistance to Sulfanilamide with IC50 of >800 μg/mL [2]. Administration of Sulfanilamide with the dosage of 100 mg/kg/day is effective in the prevention of P. carinii infection in the immunosuppressed rat model. When the dosage of sulfaguanidine and Sulfanilamide reduced to 10 mg/kg/day, breakthrough P. carinii infection occurs in the rats [3].

Molecular Weight









Room temperature in continental US; may vary elsewhere

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (174.22 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8072 mL 29.0360 mL 58.0720 mL
5 mM 1.1614 mL 5.8072 mL 11.6144 mL
10 mM 0.5807 mL 2.9036 mL 5.8072 mL
*Please refer to the solubility information to select the appropriate solvent.

Purity: 99.89%

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