108 Results for "

Scopolamine

" in MedChemExpress (MCE) Product Catalog:
Products (108)

108 Results for "Scopolamine" in MCE Product Catalog:

21
Scopolamine hydrobromide trihydrate
Scopolamine hydrobromide trihydrate
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21 Publications Verification
Cat. No.: HY-W010892
CAS No.: 6533-68-2
Synonyms: Hyoscine hydrobromide trihydrate
Category:  

Alkaloids Other Alkaloids Datura metel L. Plants Solanaceae

Target:  

mAChR 5-HT Receptor

Scopolamine (Hyoscine) hydrobromide trihydrate is a high-affinity muscarinic antagonist that can cross the blood-brain barrier. Scopolamine hydrobromide trihydrate competitively antagonizes 5-HT3 receptors with an IC50 of 2.09 μM. Scopolamine hydrobromide trihydrate can induce cognitive and memory deficits in animals. Scopolamine hydrobromide trihydrate can be used in the research of preventing postoperative nausea and vomiting, motion sickness, nervous system diseases, etc .
21
Scopolamine hydrochloride
Scopolamine hydrochloride
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21 Publications Verification
Cat. No.: HY-B2065
CAS No.: 55-16-3
Synonyms: (-)-Scopolamine hydrochloride; Hyoscine hydrochloride
Category:  

Alkaloids Other Alkaloids Atropa belladonna Linn. Plants Solanaceae

Target:  

mAChR 5-HT Receptor

Scopolamine (Hyoscine) hydrochloride is a high-affinity muscarinic antagonist that can cross the blood-brain barrier. Scopolamine hydrochloride competitively antagonizes 5-HT3 receptors with an IC50 of 2.09 μM. Scopolamine hydrochloride can induce cognitive and memory deficits in animals. Scopolamine hydrochloride can be used in the research of preventing postoperative nausea and vomiting, motion sickness, nervous system diseases, etc .
8
Afzelin
Afzelin
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8 Cited Publications
Cat. No.: HY-N1441
CAS No.: 482-39-3
Synonyms: Kaempferol-3-O-rhamnoside
Category:  

Flavonols Saururaceae Flavonoids  Houttuynia cordata Thunb. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Mitochondrial Metabolism PTEN Autophagy Bacterial

Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .
4
Crebanine
Crebanine
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4 Cited Publications
Cat. No.: HY-N2255
CAS No.: 25127-29-1
Category:  

Cardiovascular Disease Alkaloids Stephania venosa Other Alkaloids Plants Disease Research Fields Inflammation/Immunology Menispermaceae

Target:  

Akt Apoptosis NF-κB Reactive Oxygen Species (ROS) p38 MAPK ERK Interleukin Related TNF Receptor NO Synthase nAChR Bacterial

Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC50 of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na + current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease .
3
Baimaside
Baimaside
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3 Cited Publications
Cat. No.: HY-N2183
CAS No.: 18609-17-1
Synonyms: Quercetin 3-O-sophoroside
Category:  

Apocynaceae Flavonols Flavonoids Other Diseases Phenols Polyphenols Plants  Apocynum venetum Linn. Disease Research Fields

Target:  

SARS-CoV

Baimaside (Quercetin 3-O-sophoroside) is a flavonoid cholinergic function modulator that binds to SARS-CoV-2-related targets. Baimaside regulates the expression of cholinergic system-related proteins and acetylcholine levels, improves scopolamine-induced learning and memory impairment, protects hippocampal neurons, inhibits pollen protein fluorescence, and protects pollen DNA. Its biosynthesis is regulated by multiple enzymes. Baimaside is completely absorbed in rats, undergoes phase Ⅱ metabolism and gut microbiota decomposition, and inhibits the invasion and proliferation of SARS-CoV-2 and its variants, making it suitable for research related to Alzheimer's disease and COVID-19 .
2
Scopine
Scopine
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2 Cited Publications
Cat. No.: HY-B0459
CAS No.: 498-45-3
Synonyms: 6,7-Epoxytropine
Category:  

Alkaloids Neurological Disease Datura stramonium L. Other Alkaloids Plants Solanaceae Disease Research Fields Endocrinology

Target:  

Drug Metabolite

Scopine is a metabolite of Scopolamine (HY-N0296) and brain-targeting compound. Scopine significantly increases the brain exposure of Chlorambucil (HY-13593) and enhances its anti-glioma activity. Scopine can be used in targeted therapy research for brain gliomas .
2
Scopine hydrochloride
Scopine hydrochloride
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2 Cited Publications
Cat. No.: HY-B0459A
CAS No.: 85700-55-6
Synonyms: 6,7-Epoxytropine hydrochloride
Target:  

Drug Metabolite

Research Areas:  

Neurological Disease Cancer

Scopine hydrochloride is a metabolite of Scopolamine (HY-N0296) and brain-targeting compound. Scopine hydrochloride significantly increases the brain exposure of Chlorambucil (HY-13593) and enhances its anti-glioma activity. Scopine hydrochloride can be used in targeted therapy research for brain gliomas .
1
Scopolamine butylbromide
Scopolamine butylbromide
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1 Cited Publications
Cat. No.: HY-N0340
CAS No.: 149-64-4
Synonyms: Hyoscine butylbromide; (-)-Scopolamine butylbromide; ButylScopolamine bromide
Category:  

Alkaloids Other Alkaloids Datura metel L. Plants Solanaceae

Target:  

mAChR

Scopolamine butylbromide (Hyoscine butylbromide) is an orally active anticholinergic agent and spasmolytic. Scopolamine butylbromide binds with high affinity to rat cardiac M2 (Ki 83 nmol/L), hM2 (Ki 233 nmol/L), rat intestinal M3 (Ki 290 nmol/L) and hM3 (Ki 643 nmol/L) muscarinic receptors. Scopolamine butylbromide exerts a dose-dependent antagonistic effect on Carbachol-induced gastrointestinal smooth muscle spasm. Scopolamine butylbromide can be used for the research of abdominal colic and pain associated with gastrointestinal spasm, functional abdominal pain, chronic gastropathy and gastric ulcer .
1
Aniracetam
Aniracetam
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1 Cited Publications
Cat. No.: HY-10932
CAS No.: 72432-10-1
Purity:  99.94%
Synonyms: Ro 13-5057
Target:  

nAChR iGluR

Research Areas:  

Neurological Disease

Aniracetam (Ro 13-5057) is an orally active neuroprotective agent, possessing nootropics effects. Aniracetam potentiates the ionotropic quisqualate (iQA) responses in the CA1 region of rat hippocampal slices. Aniracetam also potentiates the excitatory post synaptic potentials (EPSPs) in Schaffer collateral-commissural synapses. Aniracetam can prevents the CO2-induced impairment of acquisition in hypercapnia model rats. Aniracetam can be used to research cerebral dysfunctional disorders .
1
Soyasaponin Bb
Soyasaponin Bb
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1 Cited Publications
Cat. No.: HY-N0310
CAS No.: 51330-27-9
Category:  

Triterpenes Leguminosae Glycine max (L.) merr Terpenoids Plants Disease Research Fields Endocrinology

Target:  

Aldose Reductase Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Apoptosis

Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities .
1
Methscopolamine bromide
Methscopolamine bromide
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1 Cited Publications
Cat. No.: HY-B0344
CAS No.: 155-41-9
Synonyms: (-)-Scopolamine methyl bromide; Hyoscine methyl bromide
Target:  

mAChR

Research Areas:  

Neurological Disease

Methscopolamine bromide ((-)-Scopolamine methyl bromide; Hyoscine methyl bromide) is a peripherally acting muscarinic receptor (mAChR) antagonist that cannot cross the blood-brain barrier. Methscopolamine bromide blocks the muscarinic negative feedback regulation of acetylcholine release from striatal cholinergic terminals, thereby increasing acetylcholine release in the striatum of freely moving rats. Methscopolamine bromide does not induce motor excitation in freely moving rats, nor does it alter the duration of ethanol-induced loss of righting reflex in mice. Methscopolamine bromide fails to antagonize the arecoline-mediated reduction in the duration of ethanol-induced loss of righting reflex in mice .
1
Picein
Picein
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1 Cited Publications
Cat. No.: HY-N8698
CAS No.: 530-14-3
Category:  

Plants Nyssaceae Saccharides

Target:  

SOD Ferroptosis Keap1-Nrf2 Heme Oxygenase (HO) Glutathione Peroxidase

Picein is an antioxidant and anti-inflammatory agent. Picein can be isolated from the leaves of Picrorhiza kurroa. Picein reduces MDA levels and increases the levels of SOD, GPX and TAC. Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defects by inhibiting Ferroptosis (via activation of the Nrf2/HO-1/GPX4 pathway). Picein prevents scopolamine (HY-N0296)-induced passive avoidance memory impairment in rats. Picein can be used in research related to osteoporotic bone defects and Alzheimer's disease .
1
Soyasaponin Ab
Soyasaponin Ab
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1 Cited Publications
Cat. No.: HY-N3026
CAS No.: 118194-13-1
Category:  

Triterpenes Leguminosae Glycine max (L.) merr Terpenoids Metabolic Disease Plants Disease Research Fields

Target:  

PPAR Apoptosis Reactive Oxygen Species (ROS)

Soyasaponin Ab is an orally active soyasaponin. Soyasaponin Ab inhibits PPARγ transcriptional activity. Soyasaponin Ab induces apoptosis in high concentrations. Soyasaponin Ab exerts anti-obesity, anti-oxidation, anti-inflammation, anti-aging effects. Soyasaponin Ab prevents Scopolamine (HY-N0296)-induced memory impairment .
1
PQCA
PQCA
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1 Cited Publications
Cat. No.: HY-118342
CAS No.: 1144504-35-7
Purity:  99.96%
Target:  

mAChR

Research Areas:  

Neurological Disease

PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively. PQCA is inactive for other muscarinic receptors. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease .
1
AS19
AS19
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1 Cited Publications
Cat. No.: HY-103142
CAS No.: 1000578-26-6
Purity:  99.78%
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia .
1
Azaphen dihydrochloride monohydrate
Azaphen dihydrochloride monohydrate
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1 Cited Publications
Cat. No.: HY-A0022A
CAS No.: 63302-99-8
Synonyms: Azafen dihydrochloride monohydrate; Pipofezin dihydrochloride monohydrate; Pipofezine dihydrochloride monohydrate; Azaphenonxazine dihydrochloride monohydrate
Target:  

Serotonin Transporter

Research Areas:  

Neurological Disease

Azaphen (Pipofezin) dihydrochloride monohydrate is an orally active serotonin reuptake inhibitor. Azaphen dihydrochloride monohydrate potentiates sympathomimetic compound effects. Azaphen dihydrochloride monohydrate can be used for the research of depressive states .
1
3′,4′,7-Trihydroxyflavone
3′,4′,7-Trihydroxyflavone
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1 Cited Publications
Cat. No.: HY-N2736
CAS No.: 2150-11-0
Category:  

Flavonoids Leguminosae Flavones Other Diseases Phenols Polyphenols Plants Vicia faba L. Disease Research Fields

Target:  

Beta-lactamase COX Interleukin Related Bacterial JNK ERK p38 MAPK STAT Apoptosis NO Synthase Nuclear Factor of activated T Cells (NFAT) Lactate Dehydrogenase Reactive Oxygen Species (ROS) SOD Akt Caspase Bcl-2 Family

3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC50 = 1.89 μM) and COX-1 (IC50 = 36.37 μM). 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H2O2-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice .
MK-7622
MK-7622
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Cat. No.: HY-15618
CAS No.: 1227923-29-6
Purity:  99.89%
Synonyms: M1 receptor modulator
Target:  

mAChR Calcium Channel

Research Areas:  

Neurological Disease

MK-7622 (M1 receptor modulator) is an orally active positive allosteric modulator of muscarinic M1 acetylcholine receptors (mAChRs). MK-7622 enhances ACh-induced calcium flux in CHO cells expressing human M1 receptors (EC50 = 21 nM) and shows robust agonist activity in rat M1-expressing CHO cells, increasing intracellular calcium. MK-7622 reverses Scopolamine (HY-N0296)-induced cognitive deficits in rhesus macaques in an object retrieval detour task. MK-7622 can be used for the study of Alzheimer's disease (AD) .
Phenylpiracetam
Phenylpiracetam
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Cat. No.: HY-14840
CAS No.: 77472-70-9
Purity:  99.58%
Synonyms: Carphedon
Target:  

nAChR Dopamine Transporter GABA Receptor iGluR

Research Areas:  

Neurological Disease

Phenylpiracetam (Carphedon) is a positive allosteric modulator of nicotinic acetylcholine receptors (nAChR) with an IC50 of 5.86 μM. Phenylpiracetam is applicable to studies on scopolamine (Scopolamine) (HY-N0296)-induced amnesia, depression and immune stress .
Tropine
Tropine
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Cat. No.: HY-N7061
CAS No.: 120-29-6
Category:  

Alkaloids Other Alkaloids Plants Solanaceae  Przewalskia tangutica Maximo.

Target:  

Drug Intermediate

Tropine is a tropane alkaloid. Tropine serves as an important intermediate for the synthesis of anticholinergics and bronchodilators such as Atropine (HY-B1205) and Scopolamine (HY-N0296) .
Assay Types