1144504-35-7
Chemical Structure
PQCA
- CAS No.: 1144504-35-7
- Formula:C22H20N4O3
- Molecular Weight:388.42
IUPAC Name: 1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid
InChIKey: RJTJRVASUFIDQM-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(CN2CCC(C#N)(CC2)C3=NC=CC=C3)=C4C=CC=CN4C1=O
Biological Activity: PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively. PQCA is inactive for other muscarinic receptors. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PQCA | 99.96% | PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively. PQCA is inactive for other muscarinic receptors. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.48
HY-101348RL-741626 (Standard) -
Similarity Score 0.47
HY-145840Pol I-IN-1 -
Similarity Score 0.46
HY-100930L-693403 maleate -
Similarity Score 0.46
HY-143477Factor XI-IN-1 -
Similarity Score 0.46
HY-12842UC-112 -
Similarity Score 0.46
HY-B1737Pirenperone -
Similarity Score 0.46
HY-160647CCR8 antagonist 3 -
Similarity Score 0.46
HY-100769Hypidone hydrochloride -
Similarity Score 0.46
HY-183404Wy 25093 -
Explore the MedChemAI to find more analogs
References
- [1]. Lange HS, et al. The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys. J Pharmacol Exp Ther. 2015 Dec;355(3):442-50. [Content Brief]
- [2]. Uslaner JM, et al. The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque. Psychopharmacology (Berl). 2013 Jan;225(1):21-30. [Content Brief]
