Wy 25093
Wy 25093 is a selective serotonin (5-HT) uptake transporter inhibitor. Wy 25093 regulates the turnover and metabolism of central 5-HT, enhances postsynaptic 5-HT actions and 5-hydroxytryptophan-induced behavioral syndrome. Wy 25093 induces ipsilateral and contralateral circling behavior in rats, reduces the turnover rate of striatal dopamine, decreases the level of 5-hydroxyindole-3-acetic acid in the brain, and long-term administration reduces brain 5-HT levels. Wy 25093 can be used in research related to depression.
For research use only. We do not sell to patients.
- CAS No.: 72807-01-3
- Formula: C22H24N4O2
- Molecular Weight:376.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Wy 25093 (100 μM; pre-incubated for 10 min; substrate uptake for 10 min) reduces the tissue-to-medium ratio of 5-HT uptake from 36.6 to 6.7 in freshly isolated rat substantia nigra tissues, and does not significantly alter NA or DA uptake[1].
Wy 25093 inhibits 5-HT uptake in brain cortical slices of rats and Patas monkeys, with IC50 values of 0.11 μM and 0.012 μM, respectively.[2]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Wy 25093 (200 μg; stereotaxic intracaudate injection) induces weak contralateral circling behavior[2].
Wy 25093 (50 mg/kg) potently inhibits p-chloroamphetamine-induced whole-brain 5HT depletion in male Sprague-Dawley rats, with a duration of action of at least 24 h[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar albino (male, 160-180 g)[2]
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Dosage:10 μg
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Administration:stereotaxic intranigral injection
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Result:Elicited ipsiversive circling, increased ipsilateral striatal DA by 9.0%, and reduced HVA by 27.1%.
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Animal Model:Wistar albino (male, 160-180 g)[2]
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Dosage:200 μg
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Administration:stereotaxic intracaudate injection
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Result:Elicited weak contraversive circling.
Chemical Information
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CAS No. 72807-01-3
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Molecular Weight 376.45
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Formula C22H24N4O2
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SMILES
O=C(NC1CCN(CC1)CC2=CNC3=C2C=CC=C3)NC(C4=CC=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Diggory GL, et al. Behavioural and neurochemical proteins of 1-[1-([indol-3-yl] methyl) piperid-4-yl]-3-benzoylurea (Wy 25093) in rodents. Archives internationales de pharmacodynamie et de therapie. 1980 Nov;248(1):86-104. [Content Brief]
[2]. James TA, et al. Rotational behaviour elicited by 5-HT in the rat: evidence for an inhibitory role of 5-HT in the substantia nigra and corpus striatum. The Journal of pharmacy and pharmacology. 1980 Mar;32(3):196-200. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Wy 25093 Related Classifications
HY-183404 Related Classifications
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