72807-01-3
Chemical Structure
Wy 25093
- CAS No.: 72807-01-3
- Formula:C22H24N4O2
- Molecular Weight:376.45
InChIKey: LBRHJTCPPZIPJU-UHFFFAOYSA-N
SMILES: O=C(NC1CCN(CC1)CC2=CNC3=C2C=CC=C3)NC(C4=CC=CC=C4)=O
Biological Activity: Wy 25093 is a selective serotonin (5-HT) uptake transporter inhibitor. Wy 25093 regulates the turnover and metabolism of central 5-HT, enhances postsynaptic 5-HT actions and 5-hydroxytryptophan-induced behavioral syndrome. Wy 25093 induces ipsilateral and contralateral circling behavior in rats, reduces the turnover rate of striatal dopamine, decreases the level of 5-hydroxyindole-3-acetic acid in the brain, and long-term administration reduces brain 5-HT levels. Wy 25093 can be used in research related to depression[1][2][3].
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Wy 25093 | Wy 25093 is a selective serotonin (5-HT) uptake transporter inhibitor. Wy 25093 regulates the turnover and metabolism of central 5-HT, enhances postsynaptic 5-HT actions and 5-hydroxytryptophan-induced behavioral syndrome. Wy 25093 induces ipsilateral and contralateral circling behavior in rats, reduces the turnover rate of striatal dopamine, decreases the level of 5-hydroxyindole-3-acetic acid in the brain, and long-term administration reduces brain 5-HT levels. Wy 25093 can be used in research related to depression. | |||||||||||||||||||||
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References
- [1]. Diggory GL, et al. Behavioural and neurochemical proteins of 1-[1-([indol-3-yl] methyl) piperid-4-yl]-3-benzoylurea (Wy 25093) in rodents. Archives internationales de pharmacodynamie et de therapie. 1980 Nov;248(1):86-104. [Content Brief]
- [2]. James TA, et al. Rotational behaviour elicited by 5-HT in the rat: evidence for an inhibitory role of 5-HT in the substantia nigra and corpus striatum. The Journal of pharmacy and pharmacology. 1980 Mar;32(3):196-200. [Content Brief]
- [3]. Diggory GL, et al. Changes in Central 5-Hydroxytryptamine Turnover Induced by Acute and Chronic Inhibition of the Re-uptake Process. In: Central Neurotransmitter Turnover. 1981:149-150.
