1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. PQCA

PQCA 

Cat. No.: HY-118342
Handling Instructions

PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively, and is inactive for other muscarinic receptors. PQCA improves cognitive performance and cerebral blood flow in rat, cynomolgus macaque, and rhesus macaque. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease.

For research use only. We do not sell to patients.

PQCA Chemical Structure

PQCA Chemical Structure

CAS No. : 1144504-35-7

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Description

PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively, and is inactive for other muscarinic receptors. PQCA improves cognitive performance and cerebral blood flow in rat, cynomolgus macaque, and rhesus macaque. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease[1][2].

IC50 & Target

EC50: 49 nM (Rhesus M1 receptor) and 135 nM (Human M1 receptor)[1]

In Vivo

PQCA (3-30 mg/kg; Oral administration; single- or pair-housed male rhesus monkeys) treatment attenuates the scopolamine deficits in PAL and CPT tasks. Blockade of muscarinic signaling by scopolamine produces significant impairments in both tasks[1].

Animal Model: Ten single- or pair-housed male rhesus monkeys (6-10 years old; 5.2-10.5 kg) with scopolamine[1]
Dosage: 3 mg/kg, 10 mg/kg, or 30 mg/kg
Administration: Oral administration
Result: Attenuated the scopolamine deficits in paired-associates learning (PAL) and the continuous-performance task (CPT).
Molecular Weight

388.42

Formula

C₂₂H₂₀N₄O₃

CAS No.

1144504-35-7

SMILES

O=C(O)C1=CC(CN2CCC(C#N)(CC2)C3=NC=CC=C3)=C4C=CC=CN4C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PQCAmAChRMuscarinic acetylcholine receptorMemorytranslatableM1scopolamineAlzheimer'sdiseasecognitivecerebralbloodflowInhibitorinhibitorinhibit

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PQCA
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HY-118342
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