Art. -Nr.: HY-N0310

Soyasaponin Bb

1 Cited Publications

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Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities.

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Reinheit: 99.88%
CAS. Nr.: 51330-27-9
Formel: C₄₈H₇₈O₁₈
Molecular Weight:943.12

Speicherung:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Soyasaponin Bb Chemical Structure

CAS. Nr.: 51330-27-9

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

HO-1

Alle Heme Oxygenase (HO) Isoform-spezifische Produkte anzeigen :

HO-1
HO-2

In Vitro

Soyasaponin Bb (25-100 μg/mL; pretreatment for 24 h + ethanol treatment for 24 h) increases cell viability, reduces reactive oxygen species (ROS) levels, increases superoxide dismutase (SOD) and glutathione (GSH) activities, downregulates malondialdehyde (MDA) and alanine aminotransferase (ALT) levels, and induces heme oxygenase-1 (HO-1) expression in rat hepatocyte BRL 3A assay^[1].
Soyasaponin Bb (2.36-94.30 mg/L; 4 h) shows no significant cytotoxicity in the Caco-2 intestinal epithelial cell experiment. Soyasaponin Bb has an apparent permeability (P_app) across the membrane of less than 1.0×10^-6 cm/s), with the apical-to-basolateral (AP-BL) transport significantly higher than the basolateral-to-apical (BL-AP) transport, indicating that the cell permeation of Soyasaponin Bb is mainly passive transport^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Rat BRL 3A hepatocytes
Concentration:

0, 25, 50, 100 μg/mL
Incubation Time:

24 h pretreatment with Soyasaponin Bb, followed by 24 h ethanol (250 mmol/L) treatment
Result:

Dose-dependently increased cell viability, with 50 and 100 μg/mL groups showing significant protection compared to the ethanol-alone group.
The 25 μg/mL group showed minimal improvement.

In Vivo

Soyasaponin Bb (100 mg/kg; oral administration; single dose) showes a peak plasma drug concentration of 19.8 ng/mL in the Sprague-Dawley rat model. It was mainly excreted in the feces, with very little excretion in the urine. The metabolite Soyasapogenol B was only detected in the feces^[2].
Soyasaponin Bb (10 mg/kg; oral administration; once a day; for 5 consecutive days) significantly improves passive avoidance, Y-maze and Morris water maze task performance in the Scopolamine (HY-N0296)-induced mouse memory impairment model, increases brain-derived neurotrophic factor (BDNF) expression and cyclic adenosine monophosphate response element binding protein (CREB) phosphorylation level, without inhibiting acetylcholinesterase (AChE) activity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Scopolamine-induced ICR mice Memory Impairment Model (male; 18-22 g, 5 weeks old)^[3]
Dosage:

10 mg/kg
Administration:

Oral gavage, once 1 hour before scopolamine injection, single dose
Result:

Significantly increased the latency time to enter the dark compartment in the retention trial, restoring memory impairment to 97% of the untreated normal control level, comparable to the positive control tacrine (10 mg/kg).
No significant differences were observed during the acquisition trial.

Chemical Information

CAS. Nr. 51330-27-9
Appearance Solid
Molecular Weight 943.12
Formel C₄₈H₇₈O₁₈
Color White to off-white
SMILES

O[C@H]([C@H]1O[C@@]2([H])[C@H](O[C@]3([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)[C@H](O)[C@@H](C(O)=O)O[C@@]1([H])O[C@@H]4[C@@](CO)(C)[C@]5([H])CC[C@@]6(C)[C@]7(C)CC[C@@]8(C)[C@H](O)CC(C)(C)C[C@@]8([H])C7=CC[C@]6([H])[C@@]5(C)CC4
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Journal Impact Factor

Food Chem

Activation of bitter taste receptors by saponins and alkaloids identified in faba beans (Vicia faba L. minor). [Abstract]

2023 Nov 15:426:136548. PMID: 37302309

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (106.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0603 mL

5.3016 mL

10.6031 mL

5 mM

0.2121 mL

1.0603 mL

2.1206 mL

10 mM

0.1060 mL

0.5302 mL

1.0603 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (2.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lijie Z, et al. Soyasaponin Bb Protects Rat Hepatocytes from Alcohol-Induced Oxidative Stress by Inducing Heme Oxygenase-1. Pharmacogn Mag. 2016 Oct-Dec;12(48):302-306 [Content Brief]

[2]. Xiao L, et al. Soyasaponin Bb has poor absorption and bioavailability in Sprague–Dawley rats and Caco-2 intestinal epithelial cell model[J]. Food, Nutrition and Health, 2025, 2(1): 1-13.

[3]. Hong SW, et al. Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase. J Agric Food Chem. 2014 Mar 5;62(9):2062-8. [Content Brief]

[4]. Balestri F, et al. Soyasaponins from Zolfino bean as aldose reductase differential inhibitors. J Enzyme Inhib Med Chem. 2019 Dec;34(1):350-360. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0603 mL	5.3016 mL	10.6031 mL	26.5078 mL
	5 mM	0.2121 mL	1.0603 mL	2.1206 mL	5.3016 mL
	10 mM	0.1060 mL	0.5302 mL	1.0603 mL	2.6508 mL
	15 mM	0.0707 mL	0.3534 mL	0.7069 mL	1.7672 mL
	20 mM	0.0530 mL	0.2651 mL	0.5302 mL	1.3254 mL
	25 mM	0.0424 mL	0.2121 mL	0.4241 mL	1.0603 mL
	30 mM	0.0353 mL	0.1767 mL	0.3534 mL	0.8836 mL
	40 mM	0.0265 mL	0.1325 mL	0.2651 mL	0.6627 mL
	50 mM	0.0212 mL	0.1060 mL	0.2121 mL	0.5302 mL
	60 mM	0.0177 mL	0.0884 mL	0.1767 mL	0.4418 mL
	80 mM	0.0133 mL	0.0663 mL	0.1325 mL	0.3313 mL
	100 mM	0.0106 mL	0.0530 mL	0.1060 mL	0.2651 mL

Keywords

Soyasaponin Bb

1 Cited Publications

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Soyasaponin Bb

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Publications Citing Use of MedChemExpress (MCE) Soyasaponin Bb

Alle Heme Oxygenase (HO) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Soyasaponin Bb Related Classifications

HY-N0310 Related Classifications