Fabaceae Extract

Koparin is a minor isoflavone constituent that can be isolated from the wood of Castanospermum austral.

Geraldol is a Flavonoids product that can be isolated from the herbs of Lotus corniculatus L..

2-(Methylamino) ethanol (N-Methylethanolamine) is an orally active Phospholipase D inhibitor and analog of Ethanolamine (HY-Y0524). 2-(Methylamino) ethanol reduces the mRNA levels of ACE, ppET-1 and ECE-1, and inhibits MMP-2 activity. 2-(Methylamino) ethanol inhibits Collagen synthesis. 2-(Methylamino) ethanol attenuates ventricular hypertrophy, prevents increased myocardial stiffness and hemodynamic deterioration. 2-(Methylamino) ethanol can capture industrial acid gases and react with carbon dioxide to form carbamates and bicarbonates. 2-(Methylamino) ethanol can be used in studies related to hypertensive heart failure (diastolic heart failure).

Sotolone (Dimethylhydroxyfuranone) is an activator of the human olfactory receptor OR8D1. Sotolone activates the human olfactory receptor OR8D1, with EC₅₀ values of 84.98 μM and 167.2 μM for its S-enantiomer and R-enantiomer, respectively. Sotolone has unique aroma profiles: (R)-sotolone exhibits smoky, burnt, herbal and grassy notes; (S)-sotolone presents sweet, milky, sour and nutty notes. Sotolone also acts as an antifungal agent, showing moderate inhibitory activity against Magnaporthe oryzae in vitro.

Afromosin is an isoflavone, that can be isolated from Millettia dielsiana Harms. Afromosin exhibits remarkable tumor inhibitory effects.

Cassaine (Nervocidine) is a Na⁺/K⁺-ATPase inhibitor. Cassaine stabilizes phosphorylated intermediates, slows spontaneous dephosphorylation and blocks potassium-stimulated dephosphorylation. Cassaine exhibits non-competitive inhibition with respect to K⁺, shows inhibition enhanced by Pi and antagonized by Na⁺. Cassaine induces positive inotropic effects in perfused hearts with faster inotropy offset. Cassaine can be used for research on cardiac arrhythmias.

Obtusaquinone is a blood-brain barrier-permeable Keap1 inhibitor with anticancer activity. Obtusaquinone covalently binds to cysteine residues of Keap1, promotes its ubiquitination and proteasomal degradation, and activates the Nrf2 pathway. Obtusaquinone induces endoplasmic reticulum stress and DNA damage through abnormal accumulation of ROS, and triggers apoptosis of cancer cells. Obtusaquinone prolongs survival in orthotopic xenograft models of pediatric high-grade glioma, and exhibits antitumor activity in glioblastoma and breast cancer models. Obtusaquinone can be used in studies related to glioma and breast cancer.

4-Nitrocinnamic acid is a Phenylpropanoids product that can be isolated from the heartwoods of Cassia garrettiana.

3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC₅₀=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm.

6'',6''-Dimethylchromeno-[2'',3'':7,8]-flavone (Compound 12) is a prenylated flavone that can be found in the roots of Dahlstedtia pentaphylla.

5,7,4'-Trihydroxy-3,8-dimethoxyflavone is a natural flavonoid.

Haginin D is an isoflavonoid phenolic compound found in the stems of Lespedeza homoloba. Haginin D suppresses lipid peroxidation in rat brain homogenates. Haginin D scavenges superoxide anion free radicals. Haginin D can be used in studies of oxidative damage and allergic reactions.

Cassialoin is an orally active anthrone-C-glucoside natural product with antitumor activity, which is found in the heartwood of Cassia garrettiana. Cassialoin is metabolized to the active substance Chrysophanol‑9‑anthrone. Cassialoin does not directly inhibit the activities of VEGFR‑2 and MMP‑9 in vitro, nor does it directly inhibit vascular lumen formation and cell migration in vitro. Cassialoin increases the number of IFN-γ-positive CD8⁺ T cells and natural killer cells in the small intestine or spleen, and enhances IFN-γ production by splenocytes induced by Concanavalin A (HY-P2149). Cassialoin inhibits tumor growth and peritoneal invasion in colon cancer xenograft models. Cassialoin can be used for research on colon cancer.

Deoxycaesaldekarin C (Methyl vouacapenate) is a naturally occurring, orally active cassane furanoditerpene with antibacterial, antioxidant, antiplasmodial, and analgesic effects. Deoxycaesaldekarin C inhibits bacterial growth and lipid peroxidation, and scavenges free radicals. Deoxycaesaldekarin C exhibits weak antiplasmodial activity and shows analgesic activity in mouse in vivo models. Deoxycaesaldekarin C can be used in research related to pain, bacterial infections, and Plasmodium infections.

Demethylcaesaldekarin C is a cassane-type diterpene. Demethylcaesaldekarin C can be isolated from the roots of Caesalpinia bonducella. Demethylcaesaldekarin C can be used for research on malaria.

Phaseolus vulgaris polysaccharide is a polysaccharide derived from Phaseolus vulgaris.

Hedysarum polybotrys polysaccharide is a polysaccharide derived from Hedysarum polybotrys.

Erysodine is a blood-brain barrier-permeable nicotinic acetylcholine receptor (nAChR) ligand with high affinity for α4β2 nAChR, K_i = 5 nM, and it blocks nicotine-induced dopamine release and behavioral effects through competitive inhibition. Erysodine is useful for studies on alcohol dependence.

Ormosinine is a natural Ormosia alkaloid dimer consisting of a panamine unit and an ormosanine unit linked via a C21-C22 bond, and it can be converted to panamine by acid treatment or sublimation. Ormosinine serves as a tool molecule for natural product chemistry research.