(-)-Latifolin
(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities.
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- CAS No.: 10154-42-4
- Formule: C17H18O4
- Masse moléculaire:286.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
180 μM
Compound: Latifolin
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Inhibition of BACE1 (unknown origin) expressed in CHO cells coexpressing human APP gene assessed as inhibition of beta-amyloid synthesis
Inhibition of BACE1 (unknown origin) expressed in CHO cells coexpressing human APP gene assessed as inhibition of beta-amyloid synthesis
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[PMID: 24835197] |
| RAW264.7 | IC50 |
73.2 μM
Compound: 19
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
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[PMID: 23743282] |
Chemical Information
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CAS No. 10154-42-4
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Masse moléculaire 286.32
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Formule C17H18O4
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SMILES
OC1=CC([C@@H](C2=CC=CC=C2O)C=C)=C(OC)C=C1OC
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(-)-Latifolin Related Classifications
HY-N8380 Related Classifications
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