1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. AS19

AS19 

Cat. No.: HY-103142 Purity: >99.0%
Handling Instructions

AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia.

For research use only. We do not sell to patients.

AS19 Chemical Structure

AS19 Chemical Structure

CAS No. : 1000578-26-6

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10 mM * 1  mL in DMSO USD 561 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia[1][2][3].

IC50 & Target[1][3]

Human 5-HT7 Receptor

0.83 nM (IC50)

Human 5-HT7 Receptor

0.6 nM (Ki)

5-HT1A Receptor

89.7 nM (Ki)

5-HT1B Receptor

490 nM (Ki)

5-HT1D Receptor

6.6 nM (Ki)

5-HT5 Receptor

98.5 nM (Ki)

In Vitro

The proliferation of T-cell from parachlorophenylalanine-treated mice is significantly reduced, addition of AS19 (1 μM) completely restores T-cell proliferation after 48 hours[2].

In Vivo

AS19 (0.5-10 mg/kg; subcutaneous injection; for 24 hours; male Wistar rats) treatment improves memory consolidation in an autoshaping Pavlovian/instrumental learning task[1].

Animal Model: Male Wistar rats (12-week-old) with autoshaping Pavlovian/instrumental learning task[1]
Dosage: 0.5 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg
Administration: Subcutaneous injection; for 24 hours
Result: Enhanced memory formation in an autoshaping Pavlovian/instrumental learning task.
Molecular Weight

283.41

Formula

C₁₈H₂₅N₃

CAS No.

1000578-26-6

SMILES

CC1=C(C2=CC=CC3=C2CC[[email protected]](N(C)C)C3)C(C)=NN1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

AS19AS 19AS-195-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT7Alzheimer’sdiseasememoryconsolidationaged-relateddeclineamnesiaInhibitorinhibitorinhibit

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