63302-99-8
Chemical Structure
Azaphen dihydrochloride monohydrate
Synonym(s): Azafen monohydrate; Pipofezin dihydrochloride monohydrate; Pipofezine dihydrochloride monohydrate
- CAS No.: 63302-99-8
- Formula:C16H23Cl2N5O2
- Molecular Weight:388.29
IUPAC Name: 5-methyl-3-(4-methylpiperazin-1-yl)-5H-benzo[b]pyridazino[4,3-e][1,4]oxazine dihydrochloride hydrate
InChIKey: VKMOGSQJNTXLNA-UHFFFAOYSA-N
SMILES: [H]Cl.[H]Cl.CN1C2=CC=CC=C2OC3=C1C=C(N4CCN(C)CC4)N=N3.O
Biological Activity: Azaphen dihydrochloride monohydrate is an orally active tricyclic antidepressant that inhibits the reuptake of serotonin and monoamines, regulates the 5-HT2c receptor, and exerts sedative, antidepressant and anxiolytic effects. Azaphen dihydrochloride monohydrate increases the bioavailability of serotonin in the synaptic cleft, does not block muscarinic receptors or affect monoamine oxidase activity, and binds to the human serotonin transporter via salt bridges, π-stacking, π-cation and hydrophobic interactions. Azaphen dihydrochloride monohydrate can be used in studies related to depression[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Azaphen dihydrochloride monohydrate | 99.94% | Azaphen dihydrochloride monohydrate is an orally active tricyclic antidepressant that inhibits the reuptake of serotonin and monoamines, regulates the 5-HT2c receptor, and exerts sedative, antidepressant and anxiolytic effects. Azaphen dihydrochloride monohydrate increases the bioavailability of serotonin in the synaptic cleft, does not block muscarinic receptors or affect monoamine oxidase activity, and binds to the human serotonin transporter via salt bridges, π-stacking, π-cation and hydrophobic interactions. Azaphen dihydrochloride monohydrate can be used in studies related to depression. | ||||||||||||||||||||
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References
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[1]. Imran M, et al. Study of various pyridazine and phthalazine drugs with diverse therapeutically and agrochemically activities. Russ J Bioorg Chem. 2020;46(5):745-767.
- [2]. Aleeva GN, et al. Comparison of antidepressant effects of azafan, tianeptine, and paroxetine. Bulletin of experimental biology and medicine. 2009 Jul;148(1):54-6.
- [3]. Lin J, et al. Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants. Advanced therapeutics. 2024 Sep;7(9):2400117.
