Scopine
Based on 2 publication(s) in Google Scholar
Scopine is a metabolite of Scopolamine (HY-N0296) and brain-targeting compound. Scopine significantly increases the brain exposure of Chlorambucil (HY-13593) and enhances its anti-glioma activity. Scopine can be used in targeted therapy research for brain gliomas.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 498-45-3
- Formula: C8H13NO2
- Molecular Weight:155.19
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Natural Product Library
HY-L021
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Anti-Cancer Compound Library
HY-L025
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Covalent Screening Library
HY-L036
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Macrocyclic Compound Library
HY-L041
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Medicine Food Homology Compound Library
HY-L055
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Traditional Chinese Medicine Active Compound Library
HY-L065
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Alkaloids Library
HY-L071
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Drug Metabolite Library
HY-L098
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Anti-Cancer Natural Product Library
HY-L107
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Plant-Sourced Natural Product Library
HY-L115
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Cysteine Targeted Covalent Library
HY-L153
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Cysteine Targeted Covalent Fragment Library
HY-L154
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Covalent Screening Library Plus
HY-L036P
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Natural Product Library Plus
HY-L021P
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Natural Product and Natural Product-Like Compound Library
HY-L021M
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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Miao Ethnicity Medicine Compound Library
HY-L190
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Tibetan Medicine Compound Library
HY-L191
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PBCRBS Traditional Chinese Medicine Compound Library
HY-L193
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Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library
HY-L194
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RO5 Drug-like Natural Product Library
HY-L200
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HY-L205
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HY-L206
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Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library
HY-L209
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HY-L224
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HY-L238
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HY-L245
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Tonifying Traditional Chinese Medicine Monomer Compound Library
HY-L246
Publications Citing Use of MedChemExpress (MCE) Scopine
More
Biological Activity
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α adrenergic receptor |
CHLS (Scopine combined with Chlorambucil) exhibits significant anti-glioma activity in C6 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 498-45-3
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Appearance Solid
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Molecular Weight 155.19
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Formula C8H13NO2
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Color White to off-white
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SMILES
[H][C@@]12[C@]3([H])[C@@]([H])(O3)[C@@](C[C@H](O)C2)([H])N1C
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Synonyms
6,7-Epoxytropine
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Molecules
Identification of Marrubiin as a Cathepsin C Inhibitor for Treating Rheumatoid Arthritis. [Abstract]2025 Oct 23;30(21):4170. PMID: 41226133 -
Anal Bioanal Chem
Kinetic and analytical characterization of a new tropinone oxidase enzyme and its application to the simultaneous determination of the tropane alkaloids atropine and scopolamine. [Abstract]2025 Apr 10. PMID: 40208267
Solvent & Solubility
DMSO : 100 mg/mL (644.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.11 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.11 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4437 mL | 32.2186 mL | 64.4371 mL | 161.0929 mL |
| 5 mM | 1.2887 mL | 6.4437 mL | 12.8874 mL | 32.2186 mL | |
| 10 mM | 0.6444 mL | 3.2219 mL | 6.4437 mL | 16.1093 mL | |
| 15 mM | 0.4296 mL | 2.1479 mL | 4.2958 mL | 10.7395 mL | |
| 20 mM | 0.3222 mL | 1.6109 mL | 3.2219 mL | 8.0546 mL | |
| 25 mM | 0.2577 mL | 1.2887 mL | 2.5775 mL | 6.4437 mL | |
| 30 mM | 0.2148 mL | 1.0740 mL | 2.1479 mL | 5.3698 mL | |
| 40 mM | 0.1611 mL | 0.8055 mL | 1.6109 mL | 4.0273 mL | |
| 50 mM | 0.1289 mL | 0.6444 mL | 1.2887 mL | 3.2219 mL | |
| 60 mM | 0.1074 mL | 0.5370 mL | 1.0740 mL | 2.6849 mL | |
| 80 mM | 0.0805 mL | 0.4027 mL | 0.8055 mL | 2.0137 mL | |
| 100 mM | 0.0644 mL | 0.3222 mL | 0.6444 mL | 1.6109 mL |
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