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  3. Bryonolic acid

Bryonolic acid 

Cat. No.: HY-N2965
Handling Instructions

Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities.

For research use only. We do not sell to patients.

Bryonolic acid Chemical Structure

Bryonolic acid Chemical Structure

CAS No. : 24480-45-3

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Description

Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities[1][2][3].

In Vitro

Bryonolic acid exerts anti-allergic activity by inhibiting homologous passive cutaneous anaphylaxis and delayed hypersensitivity. Bryonolic acid reduces nitric oxide by suppressing inducible nitric oxide synthase expression, indicating anti-inflammatory activity[1].
In rat adrenal pheochromocytoma (PC12) cells, Bryonolic acid against N-methyl-D-aspartate (NMDA)-induced neurotoxicity, indicating it as a candidate neuroprotective agent for cerebral ischemic treatment[1].
Bryonolic acid (1-200 μM) inhibits acyl-coA: cholesterol acyl transferase (ACAT) activity in rat liver microsomes in a concentration-dependent manner, blocking the biosynthesis of the cholesterol fatty acid ester tumour promoter. Bryonolic acid inhibits ACAT in intact cancer cells with an IC50 of 12.6 µM[2].
Bryonolic acid inhibits both clonogenicity and invasiveness in MCF-7 MB-231, U87 and 3T3-EA cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bryonolic acid (500 mg/kg; i.p.; once) potently induces HO-1 in a manner dependent on the Nrf2-Keap1 pathway[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type and Nrf2-/- mice[3]
Dosage: 500 mg/kg
Administration: i.p.; once
Result: Induced HO-1 in a manner dependent on the Nrf2-Keap1 pathway.
Molecular Weight

456.70

Formula

C₃₀H₄₈O₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Bryonolic acid
Cat. No.:
HY-N2965
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