2. Immunology/Inflammation
  3. NO Synthase Interleukin Related
  4. Isomucronulatol 7-O-glucoside

Isomucronulatol 7-O-glucoside  (Synonyms: Isomucronulatol 7-O-β-glucoside)

製品番号: HY-N6250 純度: 99.40%
COA 取扱説明書 Technical Support

Isomucronulatol 7-O-glucoside (Isomucronulatol 7-O-β-D-glucoside) is an isoflavonoid glycoside isolated from the roots of Astragalus membranaceus. Isomucronulatol 7-O-glucoside targets inflammation-related pathways in vitro to exert anti-inflammatory activity without cytotoxicity at effective concentrations. Isomucucronulatol 7-O-glucoside inhibits NO production and weakly suppresses IL‑12 p40 production in vitro. Isomucronulatol 7-O-glucoside can be used for the research on inflammation.

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Isomucronulatol 7-O-glucoside

Isomucronulatol 7-O-glucoside 構造式

CAS 番号 : 136087-29-1

容量 価格（税別） 在庫状況 数量
5 mg $240 在庫あり
10 mg $400 在庫あり
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100 mg   お問い合わせ  

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Based on 1 publication(s) in Google Scholar

Isomucronulatol 7-O-glucoside 関連抗体

Top Publications Citing Use of Products

NO Synthase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
nNOS iNOS eNOS

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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製品説明

Isomucronulatol 7-O-glucoside (Isomucronulatol 7-O-β-D-glucoside) is an isoflavonoid glycoside isolated from the roots of Astragalus membranaceus. Isomucronulatol 7-O-glucoside targets inflammation-related pathways in vitro to exert anti-inflammatory activity without cytotoxicity at effective concentrations. Isomucucronulatol 7-O-glucoside inhibits NO production and weakly suppresses IL‑12 p40 production in vitro. Isomucronulatol 7-O-glucoside can be used for the research on inflammation[1][2].

IC50 & Target[1]

IL-12

 

体外実験

Isomucronulatol 7-O-glucoside (compound 12) (25.0 μM; 1 h pre-incubation, 18 h LPS stimulation) weakly inhibits LPS-stimulated IL-12 p40 production in bone marrow-derived dendritic cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isomucronulatol 7-O-glucoside 関連抗体

ELISA Assay[1]

Cell Line: bone marrow-derived dendritic cells (BMDCs)
Concentration: 25.0 μM
Incubation Time: 1 h (pre-incubation); 18 h (LPS stimulation)
Result: Exhibited a weak inhibitory effect on LPS-stimulated IL-12 p40 production.
分子量

464.46

分子式

C23H28O10
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OC1=C([C@H]2CC3=CC=C(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO)C=C3OC2)C=CC(OC)=C1OC
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (215.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1530 mL 10.7652 mL 21.5304 mL
5 mM 0.4306 mL 2.1530 mL 4.3061 mL
10 mM 0.2153 mL 1.0765 mL 2.1530 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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C2

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体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.40%

COA (261 KB) RP-HPLC (184 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1530 mL 10.7652 mL 21.5304 mL 53.8259 mL
5 mM 0.4306 mL 2.1530 mL 4.3061 mL 10.7652 mL
10 mM 0.2153 mL 1.0765 mL 2.1530 mL 5.3826 mL
15 mM 0.1435 mL 0.7177 mL 1.4354 mL 3.5884 mL
20 mM 0.1077 mL 0.5383 mL 1.0765 mL 2.6913 mL
25 mM 0.0861 mL 0.4306 mL 0.8612 mL 2.1530 mL
30 mM 0.0718 mL 0.3588 mL 0.7177 mL 1.7942 mL
40 mM 0.0538 mL 0.2691 mL 0.5383 mL 1.3456 mL
50 mM 0.0431 mL 0.2153 mL 0.4306 mL 1.0765 mL
60 mM 0.0359 mL 0.1794 mL 0.3588 mL 0.8971 mL
80 mM 0.0269 mL 0.1346 mL 0.2691 mL 0.6728 mL
100 mM 0.0215 mL 0.1077 mL 0.2153 mL 0.5383 mL
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Isomucronulatol 7-O-glucoside Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isomucronulatol 7-O-glucoside136087-29-1Isomucronulatol 7-O-β-glucosideNO SynthaseInterleukin RelatedNitric oxide synthasesNOSILisoflavonoid glycosideflavonoidLPSbone marrow-derived dendritic cellsIL-12 p40Astragalus membranaceusInhibitorinhibitorinhibit

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製品名:
Isomucronulatol 7-O-glucoside
製品番号:
HY-N6250
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