Cat. No.: HY-111326

Naphazoline

(Synonyms: Naphthazoline)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline can be used for non-bacterial conjunctivitis research.

For research use only. We do not sell to patients.

Purity: 99.74%
CAS No.: 835-31-4
Formula: C₁₄H₁₄N₂
Molecular Weight:210.27

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Naphazoline Chemical Structure

CAS No.: 835-31-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IL-1β

IL-6

IL-4

All Adrenergic Receptor Isoforms :

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

All VEGFR Isoforms :

In Vivo

Naphazoline (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin))^[1]
Dosage:

0.2 mg/mL, 10 µl per eye
Administration:

Intraperitoneal injection (IP), once
Result:

Significantly suppressed conjunctival dye leakage in mice with histamine or antigen‑induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice.

Chemical Information

CAS No. 835-31-4
Appearance Solid
Molecular Weight 210.27
Formula C₁₄H₁₄N₂
Color White to light yellow
SMILES

C1(CC2=C3C=CC=CC3=CC=C2)=NCCN1
Synonyms

Naphthazoline
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Biomed Pharmacother

Identification of the atypical antipsychotic Asenapine as a direct survivin inhibitor with anticancer properties and sensitizing effects to conventional therapies. [Abstract]

2025 Jan:182:117756. PMID: 39693907

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (297.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.7558 mL

23.7789 mL

47.5579 mL

5 mM

0.9512 mL

4.7558 mL

9.5116 mL

10 mM

0.4756 mL

2.3779 mL

4.7558 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Quan L, et, al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. Mol Med Rep. 2016 Apr;13(4):3319-25. [Content Brief]

[2]. Yamaguchi I, et, al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203(1):125-31. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.7558 mL	23.7790 mL	47.5579 mL	118.8948 mL
	5 mM	0.9512 mL	4.7558 mL	9.5116 mL	23.7790 mL
	10 mM	0.4756 mL	2.3779 mL	4.7558 mL	11.8895 mL
	15 mM	0.3171 mL	1.5853 mL	3.1705 mL	7.9263 mL
	20 mM	0.2378 mL	1.1889 mL	2.3779 mL	5.9447 mL
	25 mM	0.1902 mL	0.9512 mL	1.9023 mL	4.7558 mL
	30 mM	0.1585 mL	0.7926 mL	1.5853 mL	3.9632 mL
	40 mM	0.1189 mL	0.5945 mL	1.1889 mL	2.9724 mL
	50 mM	0.0951 mL	0.4756 mL	0.9512 mL	2.3779 mL
	60 mM	0.0793 mL	0.3963 mL	0.7926 mL	1.9816 mL
	80 mM	0.0594 mL	0.2972 mL	0.5945 mL	1.4862 mL
	100 mM	0.0476 mL	0.2378 mL	0.4756 mL	1.1889 mL

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Naphazoline

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Publications Citing Use of MedChemExpress (MCE) Naphazoline

All Adrenergic Receptor Isoforms

All TNF Receptor Isoforms

All Interleukin Related Isoforms

All VEGFR Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Naphazoline Related Classifications

HY-111326 Related Classifications