2. GPCR/G Protein
    Neuronal Signaling
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    Immunology/Inflammation
    Protein Tyrosine Kinase/RTK
  3. Adrenergic Receptor
    TNF Receptor
    Interleukin Related
    VEGFR
  4. Naphazoline hydrochloride

Naphazoline hydrochloride  (Synonyms: Naphthazoline hydrochloride)

Cat. No.: HY-B0446 Purity: 98.37%
COA Handling Instructions

Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research.

For research use only. We do not sell to patients.

Naphazoline hydrochloride Chemical Structure

Naphazoline hydrochloride Chemical Structure

CAS No. : 550-99-2

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Other Forms of Naphazoline hydrochloride:

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Description

Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research[1][2].

IC50 & Target

IL-1β

 

IL-6

 

IL-4

 

In Vivo

Naphazoline hydrochloride (0.2 mg/kg, 10 µl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin))[1]
Dosage: 0.2 mg/mL, 10 µl per eye
Administration: Intraperitoneal injection (IP), once
Result: Significantly suppressed conjunctival dye leakage in mice with histamine or antigen‑induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice.
Clinical Trial
Molecular Weight

246.74

Appearance

Solid

Formula

C14H15ClN2
CAS No.
SMILES

C1(CC2=NCCN2)=CC=CC3=CC=CC=C13.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (202.64 mM; Need ultrasonic)

DMSO : ≥ 25 mg/mL (101.32 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0528 mL 20.2642 mL 40.5285 mL
5 mM 0.8106 mL 4.0528 mL 8.1057 mL
10 mM 0.4053 mL 2.0264 mL 4.0528 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 75 mg/mL (303.96 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.13 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.13 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.13 mM); Suspended solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Naphazoline550-99-2NaphthazolineAdrenergic ReceptorTNF ReceptorInterleukin RelatedVEGFRBeta ReceptorTumor Necrosis Factor ReceptorTNFRILVascular endothelial growth factor receptordecongestiveconjunctivitisvasoconstrictionvascular hyperpermeabilityinflammatory factorscytokinesinflammationInhibitorinhibitorinhibit

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