550-99-2
Chemical Structure
Naphazoline hydrochloride
Synonym(s): Naphthazoline hydrochloride
- CAS No.: 550-99-2
- Formula:C14H15ClN2
- Molecular Weight:246.74
IUPAC Name: 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole hydrochloride
InChIKey: DJDFFEBSKJCGHC-UHFFFAOYSA-N
SMILES: C1(CC2=NCCN2)=CC=CC3=CC=CC=C13.Cl
Biological Activity: Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research[1][2].
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Naphazoline hydrochloride | 99.38% | Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research. | ||||||||||||||||||||
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Naphazoline hydrochloride (Standard) | ≥98% | Naphazoline (hydrochloride) (Standard) is the analytical standard of Naphazoline (hydrochloride). This product is intended for research and analytical applications. Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research. | ||||||||||||||||||||
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Similarity Score 0.98
HY-111326Naphazoline -
Similarity Score 0.91
HY-111326ANaphazoline nitrate -
Similarity Score 0.69
HY-W140566RN-(2-Aminoethyl)-2-(naphthalen-1-yl)acetamide (Standard) -
Similarity Score 0.68
HY-W008353H-1-Nal-OH -
Similarity Score 0.68
HY-W0397632-Amino-3-(naphthalen-1-yl)propanoic acid -
Similarity Score 0.68
HY-116930S-20928 -
Similarity Score 0.67
HY-W012454Ethyl 2-(1-naphthyl)acetate -
Similarity Score 0.66
HY-W982195Napamezole hydrochloride -
Similarity Score 0.65
HY-106516Napactadine free base -
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References
- [1]. Quan L, et, al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. Mol Med Rep. 2016 Apr;13(4):3319-25. [Content Brief]
- [2]. Yamaguchi I, et, al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203(1):125-31. [Content Brief]
