1. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  2. Aldose Reductase Reactive Oxygen Species
  3. Danshenol A

Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC50 of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research.

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Danshenol A Chemical Structure

Danshenol A Chemical Structure

CAS No. : 189308-08-5

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Description

Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC50 of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research[1][2][3][4].

IC50 & Target

IC50: 0.1 μM (Aldose reductase)[3]

In Vitro

Danshenol A (10 nM; pretreatment for 1 h) alone showed no effect on the ICAM-1 expression at both mRNA and protein levels. TNF-α-induced ICAM-1 expression and subsequent adhesion of monocytes, as well as elevated reactive oxygen species (ROS) generation and NOX4 expression are all significantly reversed by Danshenol A Danshenol A inhibits TNF-α-induced ICAM-1 expression and subsequent monocyte adhesion to endothelial cells through the NOX4-dependent IKKβ/NF-κB pathway[1].
Danshenol A (1, 3, and 10 μM; pretreated for 35 min) restores apoptosis of cardiomyocytes induced by angiotensin II. Besides, Danshenol A inhibits mitochondrial redox signaling pathways in cardiomyocytes[2].
Danshenol A shows inhibited growth of K562 (IC50 = 0.53 μg/mL), T-24 (IC50 = 7.94 μg/mL), QGY (IC50 = 4.65 μg/mL) and Me180 (IC50 = 6.89 μg/mL) cell lines[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HUVEC cells
Concentration: 10 nM
Incubation Time: Pretreatment for 1 h
Result: Showed no effect on the ICAM-1 expression at both mRNA and protein levels.
In Vivo

Danshenol A (0.3-3 mg/kg; p.o; daily; for 12 weeks) ameliorates blood pressure, cardiac injury, and myocardial collagen volume and improved cardiac function in SHR rats. Danshenol A repaires the structure/function of the mitochondria, alleviated oxidative stress in the myocardium[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Forty male spontaneously hypertensive rats (SHR) and eight male Wistar-Kyoto (WKY) rats at the age of 16 weeks[2]
Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration: Orally administration; daily; for 12 weeks
Result: Ameliorated blood pressure, cardiac injury, and myocardial collagen volume and improved cardiac function.
Molecular Weight

336.38

Formula

C21H20O4

CAS No.
SMILES

O=C1[C@@](CC(C)=O)(O)C2=C(C3=C1[C@@H](C)CO3)C=CC4=C2C=CC=C4C

Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Danshenol A
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HY-122917
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