Two new abietane diterpenoids from Salvia yunnanensis

  • Planta Med. 2006 Jan;72(1):84-6. doi: 10.1055/s-2005-873184.
Gang Xu  1 ,  Li-Yan Peng ,  Lei Lu ,  Zi-Ying Weng ,  Yu Zhao ,  Xiao-Li Li ,  Qin-Shi Zhao ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.
PMID: 16450305 DOI: 10.1055/s-2005-873184
Abstract

Two new abietane Diterpenoids, yunnannin A and danshenol C, were isolated from Salvia yunnanensis together with ten known Diterpenoids, danshenol A, przewalskin, tanshinone IIA, tanshinone I, crypotanshinone, 1,2-dihydrotanshinone, tanshinlactone, 5,6-dehydrosugiol, 12-hydroxy-6,7-seco-8,11,3-abietatriene-6,7-dial and phytol. Their structures were established based on spectroscopic data, chemical reactions and comparison with literature data. Compounds were tested for their antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines. Compound showed inhibited growth of K562 (IC50=0.53 microg/mL), T-24 (IC50=7.94 microg/mL), QGY (IC50=4.65 microg/mL) and Me180 (IC50=6.89 microg/mL) cell lines while compound was inactive. Compound showed moderate inhibitory activity on QGY (IC50=16.75 microg/mL) and Me180 (IC50=5.84 microg/mL) cells.

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