Lucidone
Based on 1 Customer Validation
Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM).
For research use only. We do not sell to patients.
- CAS No.: 19956-53-7
- Formula: C15H12O4
- Molecular Weight:256.25
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
p38 MAPK |
JNK |
p50 |
p65 |
COX-2 |
NF-κB |
iNOS |
IKK |
Lucidone (10 μg/mL, 25 μg/mL; 1 h or 20 h) decreases the increase of TNF-α secretion (20 h) as well as PGE2 production (1 h) in LPS-induced (1 μg/mL) RAW 264.7 macrophages[1].
Lucidone (10 μg/mL, 25 μg/mL; 8 h) inhibits iNOS and COX-2 expression in LPS-induced (1 μg/mL) RAW 264.7 macrophages[1].
Lucidone (10 μg/mL, 25 μg/mL; 1 h) reduces the levels of p65 and of the p50 subunits of NF-κB, and phosphorylated IKK in LPS-induced (1 μg/mL) RAW 264.7 macrophages[1].
Lucidone (0-40 μM; 3 d) decreases the virus titer of DENV in Huh-7 cells infected with DENV[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 macrophages
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Concentration:5 μg/mL, 10 μg/mL, 25 μg/mL
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Incubation Time:1 hour
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Result:Inhibited LPS-induced NF-κB nuclear translocation, decreased the level of p65 and of the p50 subunits at 10 μg/mL and 25 μg/mL.
Inhibited the phosphorylation of IKK at 10 μg/mL and 25 μg/mL.
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Cell Line:Huh-7 cells infected with DENV
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Concentration:5 μM, 10 μM, 20 μM, and 40 μM
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Incubation Time:3 days
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Result:Showed no significant cell viability on Huh-7 cells, while leading to a decrease on viral load of DENV.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DENV-infected ICR mice[2]
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Dosage:0.4 mg/kg, 1 mg/kg
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Administration:Intracranial injection; 3 times dose at day 2, 4, 6 after DENV infection
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Result:Increased the survival rate and body weight of DENV-infected mice on day 7.
Chemical Information
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CAS No. 19956-53-7
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Appearance Solid
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Molecular Weight 256.25
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Formula C15H12O4
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SMILES
OC(/C=C/C1=CC=CC=C1)=C2C(C(OC)=CC\2=O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
References
[1]. Senthil Kumar KJ, et aL. Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways. Planta Med. 2009 Apr;75(5):494-500. [Content Brief]
[2]. Chen WC, et al. Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1. Virulence. 2018 Jan 1;9(1):588-603. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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