Lucidone 

Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE₂ production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC₅₀=25 μM)^[1][2].

Lucidone (10 μg/mL, 25 μg/mL; 1 h or 20 h) decreases the increase of TNF-α secretion (20 h) as well as PGE₂ production (1 h) in LPS-induced (1 μg/mL) RAW 264.7 macrophages^[1].
Lucidone (10 μg/mL, 25 μg/mL; 8 h) inhibits iNOS and COX-2 expression in LPS-induced (1 μg/mL) RAW 264.7 macrophages^[1].
Lucidone (10 μg/mL, 25 μg/mL; 1 h) reduces the levels of p65 and of the p50 subunits of NF-κB, and phosphorylated IKK in LPS-induced (1 μg/mL) RAW 264.7 macrophages^[1].
Lucidone (0-40 μM; 3 d) decreases the virus titer of DENV in Huh-7 cells infected with DENV^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lucidone (1 mg/kg; intracranial injection; 3 times for 1 week) significantly increases the survival rate and body weight of DENV-infected mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

256.25

C₁₅H₁₂O₄

19956-53-7

OC(/C=C/C1=CC=CC=C1)=C2C(C(OC)=CC\2=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Senthil Kumar KJ, et aL. Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways. Planta Med. 2009 Apr;75(5):494-500.  [Content Brief]

  [2]. Chen WC, et al. Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1. Virulence. 2018 Jan 1;9(1):588-603.  [Content Brief]