19956-53-7
Chemical Structure
Lucidone
- CAS No.: 19956-53-7
- Formula:C15H12O4
- Molecular Weight:256.25
IUPAC Name: (Z)-2-((E)-1-hydroxy-3-phenylallylidene)-4-methoxycyclopent-4-ene-1,3-dione
InChIKey: WVXIJNYYNKDLPE-UWWXTLEHSA-N
SMILES: OC(/C=C/C1=CC=CC=C1)=C2C(C(OC)=CC\2=O)=O
Biological Activity: Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM)[1][2].
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Lucidone | Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM). | |||||||||||||||||||||
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- [1]. Senthil Kumar KJ, et aL. Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways. Planta Med. 2009 Apr;75(5):494-500. [Content Brief]
- [2]. Chen WC, et al. Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1. Virulence. 2018 Jan 1;9(1):588-603. [Content Brief]
Keywords
