1. GPCR/G Protein
  2. LPL Receptor
  3. FTY720 (S)-Phosphate

FTY720 (S)-Phosphate (Synonyms: (S)-FTY720P; (S)-FTY720 phosphate)

Cat. No.: HY-15382 Purity: >98.0%
Handling Instructions

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

For research use only. We do not sell to patients.

FTY720 (S)-Phosphate Chemical Structure

FTY720 (S)-Phosphate Chemical Structure

CAS No. : 402616-26-6

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1 mg USD 220 In-stock
Estimated Time of Arrival: December 31
5 mg USD 790 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

IC50 & Target


In Vitro

FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 µM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 µM) also reduces β-arrestin recruitment to S1PR1[1].

In Vivo

FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice[1].

Molecular Weight







OC[[email protected]](CCC1=CC=C(CCCCCCCC)C=C1)(N)COP(O)(O)=O


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : < 0.1 mg/mL (insoluble)

In Vivo:
  • 1.

    FTY720 (S)-Phosphate is dissolved in sterile water[2].

Animal Administration

Mice[1] Male C57BL/6 (20-25 g) mice 8-10 weeks old receive a single intratracheal dose of bleomycin at 0.6 U/kg (or sterile saline) on Day 0 followed immediately by intraperitoneal injection of FTY720 (S)-Phosphate (0.5 mg/kg), FTY720 (0.5 mg/kg), or saline. Additional doses of FTY720 (S)-Phosphate or FTY720 are injected on Days 3 and 6. Bronchoalveolar lavage (BAL) fluid and lungs are then collected on Day 7. BAL fluid is used to detect BAL protein levels, WBC count, and WBC differential count. Lungs are perfused with saline to remove blood for Western blot, tissue albumin, and histopathology evaluation. Peripheral blood is obtained on Day 7 for examination of total cell counts and lymphocytes. Experiments are repeated 3 times. 6-10 mice are used per experimental group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: >98.0%

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