2. GPCR/G Protein
  3. LPL Receptor
  4. FTY720 (S)-Phosphate

FTY720 (S)-Phosphate  (Synonyms: (S)-FTY720P; (S)-FTY720 phosphate)

Cat. No.: HY-15382 Purity: 99.73% ee.: 99.76%
COA Handling Instructions

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FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

For research use only. We do not sell to patients.

FTY720 (S)-Phosphate Chemical Structure

FTY720 (S)-Phosphate Chemical Structure

CAS No. : 402616-26-6

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5 mg USD 520 In-stock
10 mg USD 830 In-stock
25 mg USD 1680 In-stock
50 mg USD 2690 In-stock
100 mg USD 4300 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of FTY720 (S)-Phosphate:

FTY720 (S)-Phosphate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE FTY720 (S)-Phosphate

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  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

IC50 & Target

S1PR1[1]
In Vitro

FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 µM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 µM) also reduces β-arrestin recruitment to S1PR1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FTY720 (S)-Phosphate Related Antibodies
In Vivo

FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

387.45

Formula

C19H34NO5P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@](CCC1=CC=C(CCCCCCCC)C=C1)(N)COP(O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (2.58 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5810 mL 12.9049 mL 25.8098 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    FTY720 (S)-Phosphate is dissolved in sterile water[2].

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.73% ee.: 99.76%

COA (243 KB) HNMR (204 KB) RP-HPLC (260 KB) NP-HPLC (455 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[1]

Mice[1] Male C57BL/6 (20-25 g) mice 8-10 weeks old receive a single intratracheal dose of bleomycin at 0.6 U/kg (or sterile saline) on Day 0 followed immediately by intraperitoneal injection of FTY720 (S)-Phosphate (0.5 mg/kg), FTY720 (0.5 mg/kg), or saline. Additional doses of FTY720 (S)-Phosphate or FTY720 are injected on Days 3 and 6. Bronchoalveolar lavage (BAL) fluid and lungs are then collected on Day 7. BAL fluid is used to detect BAL protein levels, WBC count, and WBC differential count. Lungs are perfused with saline to remove blood for Western blot, tissue albumin, and histopathology evaluation. Peripheral blood is obtained on Day 7 for examination of total cell counts and lymphocytes. Experiments are repeated 3 times. 6-10 mice are used per experimental group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5810 mL 12.9049 mL 25.8098 mL 64.5245 mL
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FTY720 (S)-Phosphate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FTY720 (S)-Phosphate402616-26-6(S)-FTY720P(S)-FTY720LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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