製品番号: HY-15382

FTY720 (S)-Phosphate

Name: FTY720 (S)-Phosphate
Brand: MedChemExpress
SKU: HY-15382
Price: 520.00 USD
Availability: InStock
Rating: 5 (3 reviews)

(別名: (S)-FTY720P; (S)-FTY720 phosphate)

3 Cited Publications

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 99.57%
CAS 番号: 402616-26-6
分子式: C₁₉H₃₄NO₅P
分子量:387.45

保管条件:

Powder -20°C, 3 years

* The compound is unstable in solutions, freshly prepared is recommended.

FTY720 (S)-Phosphate 構造式

CAS 番号: 402616-26-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
Publications (3)
溶剤 & 溶解度
- 体外
- 体内
プロトコル (1)
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

IC₅₀ & Target

S1PR1^[1]

LPL Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.3 nM Compound: (S)-5	Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand	[PMID: 16078855]
CHO	EC₅₀	0.3 nM Compound: (S)-5	Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand	[PMID: 16078855]
CHO	EC₅₀	0.6 nM Compound: (S)-5	Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand	[PMID: 16078855]
CHO	EC₅₀	3.1 nM Compound: (S)-5	Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand	[PMID: 16078855]
CHO	EC₅₀	>10000 nM Compound: (S)-5	Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand	[PMID: 16078855]
CHO	IC₅₀	2.1 nM Compound: (S)-FTY720-P, (S)-FTY720-Phosphate	Agonist activity at human S1P1 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay Agonist activity at human S1P1 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay	[PMID: 22119341]
CHO	IC₅₀	2.2 nM Compound: (S)-FTY720-P, (S)-FTY720-Phosphate	Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay	[PMID: 22119341]
CHO	IC₅₀	23 nM Compound: (S)-FTY720-P, (S)-FTY720-Phosphate	Agonist activity at human S1P3 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay Agonist activity at human S1P3 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay	[PMID: 22119341]
CHO	IC₅₀	5.9 nM Compound: (S)-FTY720-P, (S)-FTY720-Phosphate	Agonist activity at human S1P2 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay Agonist activity at human S1P2 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay	[PMID: 22119341]
CHO	IC₅₀	0.28 nM Compound: FTY-720-P	Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranes Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranes	[PMID: 24900286]
CHO	IC₅₀	6.3 nM Compound: FTY-720-P	Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranes Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranes	[PMID: 24900286]
CHO	EC₅₀	0.28 nM Compound: 2	Induction of internalization of C-terminal GFP-fused human S1P1 receptor expressed in CHO cell membranes after 50 mins Induction of internalization of C-terminal GFP-fused human S1P1 receptor expressed in CHO cell membranes after 50 mins	[PMID: 26924461]
CHO-K1	EC₅₀	0.027 μM Compound: 2a, FTY720-P	Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assay Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assay	[PMID: 22104144]
CHO-K1	EC₅₀	0.29 nM Compound: 2, FTY720-P	Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS binding Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS binding	[PMID: 22405291]
CHO-K1	EC₅₀	0.37 nM Compound: 2, FTY720-P	Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS binding Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS binding	[PMID: 22405291]
CHO-K1	EC₅₀	1.3 nM Compound: 2, FTY720-P	Agonist activity at rat S1P3 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS binding Agonist activity at rat S1P3 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS binding	[PMID: 22405291]
CHO-K1	EC₅₀	3.3 nM Compound: 2, FTY720-P	Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS binding Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS binding	[PMID: 22405291]
CHO-K1	EC₅₀	0.29 nM Compound: 2, FTY720-P	Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	[PMID: 24900318]
CHO-K1	EC₅₀	0.37 nM Compound: 2, FTY720-P	Agonist activity at human S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay Agonist activity at human S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	[PMID: 24900318]
CHO-K1	EC₅₀	1.3 nM Compound: 2, FTY720-P	Agonist activity at rat S1P3R expressed in CHO-K1 cells by [35S]GTPgammaS binding assay Agonist activity at rat S1P3R expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	[PMID: 24900318]
CHO-K1	EC₅₀	3.3 nM Compound: 2, FTY720-P	Agonist activity at human S1P3R expressed in CHO-K1 cells by [35S]GTPgammaS binding assay Agonist activity at human S1P3R expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	[PMID: 24900318]
CHO-K1	EC₅₀	2 nM Compound: 1-P	Agonist activity at human S1P3 receptor expressed in CHOK1 cell membranes by [35S]GTPgammaS binding assay Agonist activity at human S1P3 receptor expressed in CHOK1 cell membranes by [35S]GTPgammaS binding assay	[PMID: 24909680]
CHO-K1	EC₅₀	7 nM Compound: 1-P	Agonist activity at human S1P1 receptor expressed in CHOK1 cell membranes by [35S]GTPgammaS binding assay Agonist activity at human S1P1 receptor expressed in CHOK1 cell membranes by [35S]GTPgammaS binding assay	[PMID: 24909680]
U2OS	EC₅₀	0.4 nM Compound: FTY720P	Agonist activity at human S1P1 receptor expressed in EDG1-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay Agonist activity at human S1P1 receptor expressed in EDG1-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay	[PMID: 26687487]
U2OS	EC₅₀	94 nM Compound: FTY720P	Agonist activity at human S1P3 receptor expressed in EDG3-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay Agonist activity at human S1P3 receptor expressed in EDG3-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay	[PMID: 26687487]

体外実験

FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 μM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 μM) also reduces β-arrestin recruitment to S1PR1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

体内実験

FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 402616-26-6
性状 Solid
分子量 387.45
分子式 C₁₉H₃₄NO₅P
Color White to off-white
SMILES

OC[C@](CCC1=CC=C(CCCCCCCC)C=C1)(N)COP(O)(O)=O
別名

(S)-FTY720P; (S)-FTY720 phosphate
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years

* The compound is unstable in solutions, freshly prepared is recommended.

Publications (3)

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Journal Impact Factor

Cell Commun Signal

Regulation of CXCR4 function by S1P1 through heteromerization. [Abstract]

2025 Feb 26;23(1):111. PMID: 40012038
Front Immunol

Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. [Abstract]

2017 Oct 19:8:1345. PMID: 29097999
Commun Biol

Cell-based and isoform-selective G protein-coupled receptor kinase assays for comprehensive inhibitor evaluation. [Abstract]

2026 Jan 16;9(1):287. PMID: 41545717

溶剤 & 溶解度

体外:

DMSO : 1 mg/mL (2.58 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5810 mL

12.9049 mL

25.8098 mL

5 mM

---

10 mM

---

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

Protocol 1

FTY720 (S)-Phosphate is dissolved in sterile water^[2].

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

プロトコル

All Animals and Diseases

Inhalation Toxicity Study
Inhalation toxicity studies expose rodents to a controlled aerosol, vapor, gas, or smoke atmosphere and assess respiratory and systemic toxicity using exposure-atmosphere characterization, clinical observations, body and organ weights, bronchoalveolar lavage fluid, histopathology, blood chemistry, hematology, and, when included, molecular endpoints such as transcriptomics, proteomics, lipidomics, or tissue burden analysis. The primary biological readouts are airway irritation, pulmonary inflammation, cytotoxicity, altered surfactant or lipid homeostasis, impaired particle clearance, and tissue remodeling, reflected by BALF cell differentials, BALF protein, LDH, phosphatase activities, cytokines, lung weight, microscopic respiratory-tract lesions, and retained lung burden.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

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COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
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Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang L, et al. FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Crit Care Med. 2014 Mar;42(3):e189-99. [Content Brief]

[2]. Lingling Jia, et al. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5810 mL	12.9049 mL	25.8098 mL	64.5245 mL

Bioz

Keywords

FTY720 (S)-Phosphate

3 Cited Publications

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FTY720 (S)-Phosphate

MedChemExpress（MCE）の使用を引用している文献 FTY720 (S)-Phosphate

LPL Receptor アイソフォーム固有の製品をすべて表示

生物活性