1. GPCR/G Protein
  2. LPL Receptor

FTY720 (S)-Phosphate (Synonyms: (S)-FTY720P; (S)-FTY720 phosphate)

Cat. No.: HY-15382 Purity: >98.0%
Handling Instructions

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

For research use only. We do not sell to patients.

FTY720 (S)-Phosphate Chemical Structure

FTY720 (S)-Phosphate Chemical Structure

CAS No. : 402616-26-6

Size Price Stock Quantity
1 mg USD 220 In-stock
Estimated Time of Arrival: December 31
5 mg USD 790 Get quote
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

IC50 & Target

S1PR1[1]

In Vitro

FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 µM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 µM) also reduces β-arrestin recruitment to S1PR1[1].

In Vivo

FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5810 mL 12.9049 mL 25.8098 mL
5 mM 0.5162 mL 2.5810 mL 5.1620 mL
10 mM 0.2581 mL 1.2905 mL 2.5810 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    FTY720 (S)-Phosphate is dissolved in sterile water[2].

References
Animal Administration
[1]

Mice[1] Male C57BL/6 (20-25 g) mice 8-10 weeks old receive a single intratracheal dose of bleomycin at 0.6 U/kg (or sterile saline) on Day 0 followed immediately by intraperitoneal injection of FTY720 (S)-Phosphate (0.5 mg/kg), FTY720 (0.5 mg/kg), or saline. Additional doses of FTY720 (S)-Phosphate or FTY720 are injected on Days 3 and 6. Bronchoalveolar lavage (BAL) fluid and lungs are then collected on Day 7. BAL fluid is used to detect BAL protein levels, WBC count, and WBC differential count. Lungs are perfused with saline to remove blood for Western blot, tissue albumin, and histopathology evaluation. Peripheral blood is obtained on Day 7 for examination of total cell counts and lymphocytes. Experiments are repeated 3 times. 6-10 mice are used per experimental group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

387.45

Formula

C₁₉H₃₄NO₅P

CAS No.

402616-26-6

SMILES

OC[[email protected]](CCC1=CC=C(CCCCCCCC)C=C1)(N)COP(O)(O)=O

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
FTY720 (S)-Phosphate
Cat. No.:
HY-15382
Quantity:

FTY720 (S)-Phosphate

Cat. No.: HY-15382