1. Signaling Pathways
  2. GPCR/G Protein
  3. LPL Receptor
  4. LPL Receptor Inhibitors

LPL Receptor Inhibitors

LPAR1

LPAR2

LPAR3

LPAR5

S1PR1

S1PR2

S1PR3

S1PR4

S1PR5

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

LPL Receptor Inhibitors, Agonists, Antagonists & Modulators
Product Name LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 Purity
Siponimod        
S1PR1, EC50: 0.39 nM
S1PR2, EC50: >10000 nM
S1PR3, EC50: >1000 nM
S1PR4, EC50: 750 nM
S1PR5, EC50: 0.98 nM
98.88%
Ozanimod        
S1PR1, EC50: 1.03 nM
     
S1PR5, EC50: 8.6 nM
99.88%
Ponesimod        
S1PR1, IC50: 6 nM
 
S1PR3, IC50: 2068 nM
S1PR4, IC50: 1956 nM
S1PR5, IC50: 142 nM
99.81%
SEW​2871        
S1PR1, EC50: 13.8 nM
        99.77%
CAY10444            
S1PR3
    ≥98.0%
CYM50358              
S1PR4, IC50: 25 nM
  98.04%
H2L5186303  
LPA2 Receptor, IC50: 9 nM
              98.72%
SAR247799        
S1PR1, EC50: 12.6-493 nM
       
Cenerimod        
S1PR1, EC50: 1 nM
   
S1PR4, EC50: 2134 nM
S1PR5, EC50: 36 nM
S1PR5, EC50: 228 nM
99.43%
H2L 5765834
LPA1 Receptor, IC50: 94 nM
 
LPA3 Receptor, IC50: 752 nM
LPA5 Receptor, IC50: 463 nM
          98.36%
GLPG2938          
S1PR2
      98.82%
GRI977143  
LPA2 Receptor, EC50: 3.3 μM
              99.84%
ONO-9780307
LPA1 Receptor, IC50: 2.7 nM
                99.34%
Ozanimod hydrochloride        
S1PR1, EC50: 1.03 nM
     
S1PR5, EC50: 8.6 nM
99.19%
CYM50179              
S1PR4, EC50: 46 nM
 
RP101988        
S1PR1, EC50: 0.19 nM
     
S1PR5, EC50: 32.8 nM
98.92%
IMMH001        
S1PR1
       
L-threo Lysosphingomyelin (d18:1)        
S1PR1, EC50: 19.3 nM (human)
S1PR2, EC50: 313.3 nM (human)
S1PR3, EC50: 131.8 nM (human)
    ≥98.0%
TAK-615
LPA1 Receptor, Kd: 1.7-14.5 nM
                98.97%
ONO-0300302
LPA1 Receptor, IC50: 0.086 μM
                99.43%
S1P5 receptor agonist-1                
S1PR5, EC50: 20 nM
RP101075        
S1PR1, EC50: 0.27 nM
     
S1PR5, EC50: 5.9 nM
Siponimod hemifumarate        
S1PR1, EC50: 0.39 nM
S1PR2, EC50: >10000 nM
S1PR3, EC50: >1000 nM
S1PR4, EC50: 750 nM
S1PR5, EC50: 0.98 nM
S1p receptor agonist 2                
S1PR5
Udifitimod        
S1PR1
       
CYM-5478        
S1PR1, EC50: 1690 nM
S1PR2, EC50: 119 nM
S1PR3, EC50: 1950 nM
S1PR4, EC50: >10 μM
S1PR5, IC50: >10 μM
NSC12404  
LPA2 Receptor
             
TC-SP 14        
S1PR1, EC50: 0.042 μM
 
S1PR3, EC50: 3.47 μM
   
RP101442        
S1PR1, EC50: 2.6 nM
     
S1PR5, EC50: 171 nM