LPL Receptor Inhibitors

LPAR1

LPAR2

LPAR3

LPAR5

S1PR1

S1PR2

S1PR3

S1PR4

S1PR5

LPL Receptor Inhibitors, Agonists, Antagonists & Modulators

Product Name	LPAR1	LPAR2	LPAR3	LPAR5	S1PR1	S1PR2	S1PR3	S1PR4	S1PR5	Purity
Siponimod					S1PR1, EC₅₀: 0.39 nM	S1PR2, EC₅₀: >10000 nM	S1PR3, EC₅₀: >1000 nM	S1PR4, EC₅₀: 750 nM	S1PR5, EC₅₀: 0.98 nM	98.88%
Ozanimod					S1PR1, EC₅₀: 1.03 nM				S1PR5, EC₅₀: 8.6 nM	99.88%
Ponesimod					S1PR1, IC₅₀: 6 nM		S1PR3, IC₅₀: 2068 nM	S1PR4, IC₅₀: 1956 nM	S1PR5, IC₅₀: 142 nM	99.81%
SEW2871					S1PR1, EC₅₀: 13.8 nM					99.77%
CAY10444							S1PR3			≥98.0%
CYM50358								S1PR4, IC₅₀: 25 nM		98.04%
H2L5186303		LPA₂ Receptor, IC₅₀: 9 nM								98.72%
SAR247799					S1PR1, EC₅₀: 12.6-493 nM
Cenerimod					S1PR1, EC₅₀: 1 nM			S1PR4, EC₅₀: 2134 nM	S1PR5, EC₅₀: 36 nM S1PR5, EC₅₀: 228 nM	99.43%
H2L 5765834	LPA₁ Receptor, IC₅₀: 94 nM		LPA₃ Receptor, IC₅₀: 752 nM	LPA₅ Receptor, IC₅₀: 463 nM						98.36%
GLPG2938						S1PR2				98.82%
GRI977143		LPA₂ Receptor, EC₅₀: 3.3 μM								99.84%
ONO-9780307	LPA1 Receptor, IC₅₀: 2.7 nM									99.34%
Ozanimod hydrochloride					S1PR1, EC₅₀: 1.03 nM				S1PR5, EC₅₀: 8.6 nM	99.19%
CYM50179								S1PR4, EC₅₀: 46 nM
RP101988					S1PR1, EC₅₀: 0.19 nM				S1PR5, EC₅₀: 32.8 nM	98.92%
TAK-615	LPA1 Receptor, Kd: 1.7-14.5 nM									98.97%
ONO-0300302	LPA1 Receptor, IC₅₀: 0.086 μM									99.43%
IMMH001					S1PR1
L-threo Lysosphingomyelin (d18:1)					S1PR1, EC₅₀: 19.3 nM (human)	S1PR2, EC₅₀: 313.3 nM (human)	S1PR3, EC₅₀: 131.8 nM (human)			≥98.0%
S1P5 receptor agonist-1									S1PR5, EC₅₀: 20 nM
RP101075					S1PR1, EC₅₀: 0.27 nM				S1PR5, EC₅₀: 5.9 nM
Siponimod hemifumarate					S1PR1, EC₅₀: 0.39 nM	S1PR2, EC₅₀: >10000 nM	S1PR3, EC₅₀: >1000 nM	S1PR4, EC₅₀: 750 nM	S1PR5, EC₅₀: 0.98 nM
S1p receptor agonist 2									S1PR5
Udifitimod					S1PR1
CYM-5478					S1PR1, EC₅₀: 1690 nM	S1PR2, EC₅₀: 119 nM	S1PR3, EC₅₀: 1950 nM	S1PR4, EC₅₀: >10 μM	S1PR5, IC₅₀: >10 μM
NSC12404		LPA₂ Receptor
TC-SP 14					S1PR1, EC₅₀: 0.042 μM		S1PR3, EC₅₀: 3.47 μM
RP101442					S1PR1, EC₅₀: 2.6 nM				S1PR5, EC₅₀: 171 nM

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