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Boraginaceae

Boraginaceae (24):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0822
    Shikonin 517-89-5 99.80%
    Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
    Shikonin
  • HY-N2181
    Acetylshikonin 24502-78-1 98.10%
    Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity. Acetylshikonin is a non-selective cytochrome P450 inhibitor against all P450s (IC50 values range from 1.4-4.0 μM). Acetylshikonin is an AChE inhibitor and exhibits potent antiapoptosis activity.
    Acetylshikonin
  • HY-N6012
    (-)-Alkannin 517-88-4 99.58%
    (-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway.
    (-)-Alkannin
  • HY-N5112B
    β,β-Dimethylacrylshikonin 24502-79-2 99.64%
    β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative isolated from Lithospermum erythrorhizon Sieb. et Zucc. , promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.β,β-Dimethylacrylshikonin has anti-tumor activity.
    β,β-Dimethylacrylshikonin
  • HY-N2187
    Deoxyshikonin 43043-74-9 99.96%
    Deoxyshikonin is isolated from Arnebia euchroma with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF, indicates a prolymphangiogenesis as well as a proangiogenesis effect in vitro. Deoxyshikonin shows significant synergic antimicrobial activity against S. pneumonia (MIC=17 μg/mL), also shows significantly inhibitory activities against MRSA.
    Deoxyshikonin
  • HY-N10589
    (+)-trans-3'-Acetyl-4'-isobutyrylkhellactone 1562996-11-5
    (+)-trans-3'-Acetyl-4'-isobutyrylkhellactone, an angular-type pyranocoumarin is a natural product that can be isolated from Peucedani Radix. .
    (+)-trans-3'-Acetyl-4'-isobutyrylkhellactone
  • HY-N6880A
    (-)-Rabdosiin 119152-54-4
    (-)-Rabdosiin is a novel phenolic marker, found from Symphytum officinale L. (-)-Rabdosiin shows antioxidant, neuroprotective or anti-HIV activities.
    (-)-Rabdosiin
  • HY-N7610
    Acetylalkannin 34232-27-4 98.57%
    Acetylalkannin (Alkannin acetate) is an isohexenylnaphthazarin pigment isolated from Arnebia euchroma with antimicrobial and cytotoxic activities.
    Acetylalkannin
  • HY-N4201
    β-Hydroxyisovalerylshikonin 7415-78-3 99.83%
    Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells.
    β-Hydroxyisovalerylshikonin
  • HY-N2188
    Beta-Acetoxyisovalerylshikonin 69091-17-4 99.62%
    Beta-Acetoxyisovalerylshikonin is a naphthoquinone derivative isolated from Arnebia euchroma.
    Beta-Acetoxyisovalerylshikonin
  • HY-113845
    (+)-Intermedine 10285-06-0
    (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs).
    (+)-Intermedine
  • HY-N7774
    Echinatine N-oxide 20267-93-0
    Echinatine N-oxide is a pyrrolizidine alkaloid found in R. graeca.
    Echinatine N-oxide
  • HY-N9513
    Echimidine N-oxide 41093-89-4
    Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC50=0.347 mM).
    Echimidine N-oxide
  • HY-N5112
    (Rac)-Arnebin 1 5162-01-6
    (Rac)-Arnebin 1 ((Rac)-β,β-Dimethylacrylalkannin) is the racemate of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin. β,β-Dimethylacrylalkannin and β,β-Dimethylacrylshikonin are napthoquinones isolated from Arnebia nobilis. β,β-Dimethylacrylshikonin has anti-tumor activity.
    (Rac)-Arnebin 1
  • HY-N2592
    Isobutylshikonin 52438-12-7 99.53%
    Isobutylshikonin is a kind of shikonin pigments from hairy root culture of Lithospermum canescens.
    Isobutylshikonin
  • HY-N6930
    Shikonofuran A 85022-66-8
    Shikonofuran A is a natural product isolated from the root of Lithosperraum erythrorhizon Sieb.
    Shikonofuran A
  • HY-N9232
    Rutaevin 7-acetate 62306-81-4
    Rutaevin 7-acetate (compound 1) is a limonoid.
    Rutaevin 7-acetate
  • HY-121390
    Lasiocarpine 303-34-4
    Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide.
    Lasiocarpine
  • HY-131574
    Heliosupine N-oxide 31701-88-9
    Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC50 of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA).
    Heliosupine N-oxide
  • HY-105529
    Indicine N-oxide 41708-76-3
    Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research.
    Indicine N-oxide