1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
    Src
  3. β-Hydroxyisovalerylshikonin

β-Hydroxyisovalerylshikonin 

Cat. No.: HY-N4201
Handling Instructions

Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermium radix, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells.

For research use only. We do not sell to patients.

β-Hydroxyisovalerylshikonin Chemical Structure

β-Hydroxyisovalerylshikonin Chemical Structure

CAS No. : 7415-78-3

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Description

Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermium radix, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells[1].

IC50 & Target

IC50: 0.7 μM (EGFR), 1 μM (v-Src)[1]

Molecular Weight

388.41

Formula

C₂₁H₂₄O₇

CAS No.

7415-78-3

SMILES

CC(C)(O)CC(O[[email protected]@H](C(C1=O)=CC(C2=C1C(O)=CC=C2O)=O)C/C=C(C)\C)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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β-Hydroxyisovalerylshikonin
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HY-N4201
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